1 Result for "

Z-FF-FMK

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Z-FF-FMK" in MCE Product Catalog:

Z-FF-FMK
Z-FF-FMK
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Cat. No.: HY-141867
CAS No.: 105608-85-3
Purity:  98.71%
Synonyms: Z-Phe-Phe-FMK
Target:  

Cathepsin MEK Caspase DNA/RNA Synthesis Apoptosis

Research Areas:  

Cardiovascular Disease Neurological Disease

Z-FF-FMK (Z-Phe-Phe-FMK) is a cell-permeable, irreversible, and cysteine protease inhibitor targeting cathepsin-L. Z-FF-FMK inhibits angiotensin II-induced MEK activation in vascular walls, aortic medial remodeling, blood pressure elevation, and upregulation of cystatin C in aortic walls. Z-FF-FMK prevents β-amyloid-mediated caspase-3 activation, poly (ADP-ribose) polymerase cleavage, DNA fragmentation, and apoptosis of cortical neurons (apoptosis). Z-FF-FMK can be used in research related to hypertension and Alzheimer's disease .
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