105608-85-3
Chemical Structure
Z-FF-FMK
Synonym(s): Z-Phe-Phe-FMK
- CAS No.: 105608-85-3
- Formula:C27H27FN2O4
- Molecular Weight:462.51
IUPAC Name: benzyl ((S)-1-(((S)-4-fluoro-3-oxo-1-phenylbutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
InChIKey: CAILNONEKASNSH-ZEQRLZLVSA-N
SMILES: FCC([C@H](CC1=CC=CC=C1)NC([C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)=O
Biological Activity: Z-FF-FMK (Z-Phe-Phe-FMK) is a cell-permeable, irreversible, and cysteine protease inhibitor targeting cathepsin-L. Z-FF-FMK inhibits angiotensin II-induced MEK activation in vascular walls, aortic medial remodeling, blood pressure elevation, and upregulation of cystatin C in aortic walls. Z-FF-FMK prevents β-amyloid-mediated caspase-3 activation, poly (ADP-ribose) polymerase cleavage, DNA fragmentation, and apoptosis of cortical neurons (apoptosis). Z-FF-FMK can be used in research related to hypertension and Alzheimer's disease[1][2].
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Z-FF-FMK | 95.98% | Z-FF-FMK (Z-Phe-Phe-FMK) is a cell-permeable, irreversible, and cysteine protease inhibitor targeting cathepsin-L. Z-FF-FMK inhibits angiotensin II-induced MEK activation in vascular walls, aortic medial remodeling, blood pressure elevation, and upregulation of cystatin C in aortic walls. Z-FF-FMK prevents β-amyloid-mediated caspase-3 activation, poly (ADP-ribose) polymerase cleavage, DNA fragmentation, and apoptosis of cortical neurons (apoptosis). Z-FF-FMK can be used in research related to hypertension and Alzheimer's disease. | ||||||||||||||||||||
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[1]. Lu Y, et al. Angiotensin II-Induced vascular remodeling and hypertension involves cathepsin L/V-MEK/ERK mediated mechanism. International Journal of Cardiology. 2020 Jan 1;298:98-106.
- [2]. Boland B, et al. Abeta-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L. Neurobiol Aging. 2004;25(1):83-91. [Content Brief]
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