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benzothiazepine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bradykinin Receptor (1) Drug Derivative (1) Filovirus (3) GABA Receptor (2) Isotope-Labeled Compounds (1)
By Research Areas:	Infection (3) Inflammation/Immunology (1) Neurological Disease (3)

Inhibitors & Agonists

Peptides

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108896

Icatibant acetate 10+ Cited Publications HOE 140 acetate	Bradykinin Receptor	Inflammation/Immunology
Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC₅₀ and K_i of 1.07 nM and 0.798 nM respectively .

HY-160879

EBOV-IN-4	Filovirus	Infection
EBOV-IN-4 (compound 12), a benzothiazepine, is a potent Ebola virus (EBOV) inhibitor with 64.9% inhibitory for EBOV-GP-pseudotype virus (pEBOV) with 10 μM. EBOV-IN-4 is inactive with ASFV .

HY-160881

EBOV-IN-6	Filovirus	Infection
EBOV-IN-6 (compound 19) is benzothiazepine compound. EBOV-IN-6 has anti-pEBOV activity with a IC₅₀ value of 10 μM .

HY-160878

EBOV-IN-3	Filovirus	Infection
EBOV-IN-3 (compound 9) is benzothiazepine compound. EBOV-IN-6 has anti-pEBOV activity with a IC₅₀ value of 0.37 μM .

HY-106748

Nictiazem	Drug Derivative	Neurological Disease
Nictiazem is a 1,5-benzothiazepine derivative. Nictiazem exhibits antidepressant activity and can be used in the research of neurological diseases such as depression .

HY-105857

Thiazesim	GABA Receptor	Neurological Disease
Thiazesim is a benzothiazepine compound with a thiophene structure and acts as a GABAA receptor inhibitor, exerting anticonvulsant and antidepressant effects. Thiazesim exhibits specific pharmacological properties in animal experiments. Thiazesim reduces motor activity in rats and effectively inhibits rat killing responses, with a ratio of 2.1 between the ED₅₀ in rotarod tests and the ED₅₀ for anti-killing behavior. Thiazesim can be widely used in basic and clinical studies related to epilepsy .

HY-105857A

Thiazesim hydrochloride	GABA Receptor	Neurological Disease
Thiazesim hydrochloride is a benzothiazepine compound with a thiophene structure and acts as a GABAA receptor inhibitor, exerting anticonvulsant and antidepressant effects. Thiazesim hydrochloride exhibits specific pharmacological properties in animal experiments. Thiazesim hydrochloride reduces motor activity in rats and effectively inhibits rat killing responses, with a ratio of 2.1 between the ED₅₀ in rotarod tests and the ED₅₀ for anti-killing behavior. Thiazesim hydrochloride can be widely used in basic and clinical studies related to epilepsy .

HY-126182S2

Desacetyl Diltiazem-d3 Desacetyl diltiazem-d₃; (2S)-2-(4-Methoxyphenyl)-3β-hydroxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-1,5-benzothiazepine-4(5H)-one-d₃	Isotope-Labeled Compounds	Others
Desacetyl Diltiazem-d₃ is the deuterium labeled Desacetyl Diltiazem .

Cat. No.	Product Name	Target	Research Area

HY-108896

Icatibant acetate 10+ Cited Publications HOE 140 acetate	Bradykinin Receptor	Inflammation/Immunology
Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC₅₀ and K_i of 1.07 nM and 0.798 nM respectively .

Desacetyl Diltiazem-d3
Desacetyl Diltiazem-d₃ is the deuterium labeled Desacetyl Diltiazem .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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