2 Results for "

cynomolgus monkey CD40

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "cynomolgus monkey CD40" in MCE Product Catalog:

KHK2840
KHK2840
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Cat. No.: HY-P991918
Synonyms: IgG2-AAS

Target:  

Transmembrane Glycoprotein Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

KHK2840 is a potent CD40 agonist with a Kd value of 0.485 nM for hCD40. KHK2840 delivers agonistic signals in tumor-bearing hCD40 transgenic mice and human peripheral blood B cells. KHK2840 upregulates CD80, CD86, CD95 and IL-12p70 expression. KHK2840 enhances antitumor efficacy of anti-PD-1 antibody and Paclitaxel (HY-B0015). KHK2840 can be used for the research of cancer, such as colon cancer and melanoma .
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TNX-1500
TNX-1500
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Cat. No.: HY-P991921

Target:  

TNF Receptor Fc Receptor (FcR)

Research Areas:  

Cardiovascular Disease Endocrinology

TNX-1500 is a crystallizable fragment-modified anti-CD154 antibody. TNX-1500 contains the hu5c8 fragment antigen-binding (Fab) domain from Ruplizumab (HY-P99315) and an IgG4 Fc region engineered to reduce FcγRIIa binding. TNX-1500 has significantly weaker binding affinity to FcγRI, FcγRIIaH, FcγRIIbF, FcγRIIIaF, and FcγRIIIaV compared to hu5c8 (Kd values: 8.7 nM, 7100 nM, 4900 nM, 8000 nM, 6000 nM respectively). TNX-1500 prolongs nonhuman primate renal allograft survival, prolongs nonhuman primate cardiac allograft survival. TNX-1500 can be used for the research of allograft rejection [1] [2].
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