1 Result for "

hLIV22

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "hLIV22" in MCE Product Catalog:

Cat. No.: HY-P99682
CAS No.: 1629760-28-6
Synonyms: hLIV22

Target:  

ADC Antibodies

Research Areas:  

Cancer

Ladiratuzumab (hLIV22) is a humanized monoclonal antibody against zinc transporter LIV-1/ZIP6. Ladiratuzumab is conjugated to MMAE (HY-15162) via a cleavable dipeptide linker to synthesize an antibody-drug conjugate (ADC) Ladiratuzumab vedotin (HY-P99683). Ladiratuzumab vedotin selectively targets LIV-1 protein overexpressed on the surface of tumor cells, enters cells through antibody-mediated receptor endocytosis, releases MMAE to inhibit microtubule polymerization, and kills adjacent tumor cells with a bystander effect. Ladiratuzumab can be used in the study of solid tumors such as metastatic triple-negative breast cancer (mTNBC) .
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