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Results for "

isostere

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108939
    Aminoacyl tRNA synthetase-IN-1

    IleSA

    		 Bacterial Aminoacyl-tRNA Synthetase Infection
    Aminoacyl tRNA synthetase-IN-1 (IleSA) is an inhibitor of bacterial aminoacyl-tRNA synthetase (aaRS). Aminoacyl tRNA synthetase-IN-1 is applicable to studies on bacterial infections .
    Aminoacyl tRNA synthetase-IN-1
  • HY-13224
    AZD4877

    		Kinesin Apoptosis Mitosis Cancer
    AZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity .
    AZD4877
  • HY-136473
    CTX-0124143

    		Histone Acetyltransferase Cancer
    CTX-0124143 is a KAT6A inhibitor with a sulfonyl hydrazine skeleton .
    CTX-0124143
  • HY-163674
    Mincle agonist 1

    		Interleukin Related Inflammation/Immunology
    Mincle agonist 1 (compound 1c) is a Mincle agonist. Mincle agonist 1 can promote IL-1β expression in BMDM cells. Mincle agonist 1 can be used in immune and inflammation related research .
    Mincle agonist 1
  • HY-P1609
    CP-69799

    		Renin Enteropeptidase Cardiovascular Disease
    CP-69799 is an azahomostatine-containing oligopeptide transition-state analogue inhibitor with a hog renin IC50 of 6e-9 M, human plasma renin IC50 of 3e-7 M and Ki of 0.310 μM, and endothiapepsin Ki of 0.27 μM. CP-69799 binds endothiapepsin’s active site cleft in extended conformation, fills S4 to S3' pockets, displaces native solvent molecules, induces domain rotation, and reduces thermal mobility of endothiapepsin’s flap and helix regions. CP-69799 acts as a transition-state analogue inhibitor of hog renin and human plasma renin. CP-69799 contains a polar lysine residue at the P2' position, with a nitrogen atom replacing the P1' Cα atom of the hydroxyethylene dipeptide isostere. CP-69799 can be used for the research of hypertension .
    CP-69799
  • HY-W995365
    Nojirimycin

    		Glycosidase Metabolic Disease
    Nojirimycin is a nitrogen-containing sugar analog and glycosidase inhibitor. Nojirimycin contains a ring nitrogen atom, which acts as an isostere of the ring oxygen atom to inhibit glycosidases. Nojirimycin belongs to a class of nitrogen-containing sugar analogs with a ring nitrogen atom .
    Nojirimycin

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