Search Result

Results for "

let-7 miRNA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MicroRNA (86) Molecular Glues (1)
By Research Areas:	Cancer (68)
Oligonucleotides:	miRNA mimics (24) miRNA antagomirs (20) miRNA agomirs (20) MicroRNAs (84) miRNA inhibitors (20)

Inhibitors & Agonists

Oligonucleotides

Targets Recommended: MicroRNA

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-R00003

hsa-let-7a-5p mimic	MicroRNA	Cancer
hsa-let-7a-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7a-5p mimic hsa-let-7a-5p mimic

HY-R04633

hsa-let-7d-5p mimic	MicroRNA	Others
hsa-let-7d-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7d-5p mimic hsa-let-7d-5p mimic

HY-R00005

hsa-let-7b-5p mimic	MicroRNA	Cancer
hsa-let-7b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7b-5p mimic hsa-let-7b-5p mimic

HY-RI00003

hsa-let-7a-5p inhibitor	MicroRNA	Cancer
hsa-let-7a-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7a-5p inhibitor hsa-let-7a-5p inhibitor

HY-RI00005

hsa-let-7b-5p inhibitor	MicroRNA	Cancer
hsa-let-7b-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7b-5p inhibitor hsa-let-7b-5p inhibitor

HY-R00002

hsa-let-7a-3p mimic	MicroRNA	Cancer
hsa-let-7a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7a-3p mimic hsa-let-7a-3p mimic

HY-RI00001

hsa-let-7a-2-3p inhibitor	MicroRNA	Cancer
hsa-let-7a-2-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7a-2-3p inhibitor hsa-let-7a-2-3p inhibitor

HY-177782

SB1349	Molecular Glues MicroRNA	Cancer
SB1349 is a molecular glucose degrading agent that targets the Lin28 protein. SB1349 can effectively induce proteasome dependent degradation of Lin28A and Lin28B. SB1349 can increase the level of mature let-7 miRNA, downregulate the oncogenes targeted by let-7, and effectively induce the differentiation of neuroblastoma cells. SB1349 can be used for cancer research .

HY-R00007A

hsa-let-7c-5p agomir	MicroRNA
hsa-let-7c-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7c-5p agomir hsa-let-7c-5p agomir

HY-RI00007A

hsa-let-7c-5p antagomir	MicroRNA	Cancer
hsa-let-7c-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7c-5p antagomir hsa-let-7c-5p antagomir

HY-155237

LIN28-IN-1	MicroRNA	Cancer
LIN28-IN-1 (compound 5) is an inhibitor of the RNA-binding and regulatory protein LIN28 and binds to the LIN28 cold shock domain (CSD). LIN28-IN-1 effectively inhibits the interaction between LIN28 and let-7 miRNA (IC₅₀: 5.4 μM), blocking the negative impact of LIN28 on epigenetic gene regulation. LIN28-IN-1 significantly inhibits the proliferation of JAR cancer cells expressing LIN28 (IC₅₀: 6.4 μM) .

HY-R02560

mmu-let-7j mimic	MicroRNA	Cancer
mmu-let-7j mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-let-7j mimic mmu-let-7j mimic

HY-R02561

mmu-let-7k mimic	MicroRNA	Cancer
mmu-let-7k mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-let-7k mimic mmu-let-7k mimic

HY-R02558

mmu-let-7a-2-3p mimic	MicroRNA	Cancer
mmu-let-7a-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-let-7a-2-3p mimic mmu-let-7a-2-3p mimic

HY-R02557

mmu-let-7a-1-3p mimic	MicroRNA	Cancer
mmu-let-7a-1-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-let-7a-1-3p mimic mmu-let-7a-1-3p mimic

HY-R00001

hsa-let-7a-2-3p mimic	MicroRNA	Cancer
hsa-let-7a-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7a-2-3p mimic hsa-let-7a-2-3p mimic

HY-R00014

hsa-let-7i-5p mimic	MicroRNA	Cancer
hsa-let-7i-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7i-5p mimic hsa-let-7i-5p mimic

HY-R00013

hsa-let-7i-3p mimic	MicroRNA	Cancer
hsa-let-7i-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7i-3p mimic hsa-let-7i-3p mimic

HY-R00004

hsa-let-7b-3p mimic	MicroRNA	Cancer
hsa-let-7b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7b-3p mimic hsa-let-7b-3p mimic

HY-R00006

hsa-let-7c-3p mimic	MicroRNA	Cancer
hsa-let-7c-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7c-3p mimic hsa-let-7c-3p mimic

HY-R00008

hsa-let-7d-3p mimic	MicroRNA	Cancer
hsa-let-7d-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7d-3p mimic hsa-let-7d-3p mimic

HY-R00007

hsa-let-7c-5p mimic	MicroRNA	Cancer
hsa-let-7c-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7c-5p mimic hsa-let-7c-5p mimic

HY-R00009

hsa-let-7e-3p mimic	MicroRNA	Cancer
hsa-let-7e-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7e-3p mimic hsa-let-7e-3p mimic

HY-R00012

hsa-let-7g-5p mimic	MicroRNA	Cancer
hsa-let-7g-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7g-5p mimic hsa-let-7g-5p mimic

HY-R02559

mmu-let-7f-2-3p mimic	MicroRNA	Cancer
mmu-let-7f-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-let-7f-2-3p mimic mmu-let-7f-2-3p mimic

HY-R00010

hsa-let-7f-1-3p mimic	MicroRNA	Cancer
hsa-let-7f-1-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7f-1-3p mimic hsa-let-7f-1-3p mimic

HY-R00011

hsa-let-7f-2-3p mimic	MicroRNA	Cancer
hsa-let-7f-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7f-2-3p mimic hsa-let-7f-2-3p mimic

HY-RI02560

mmu-let-7j inhibitor	MicroRNA	Cancer
mmu-let-7j inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-let-7j inhibitor mmu-let-7j inhibitor

HY-RI02557

mmu-let-7a-1-3p inhibitor	MicroRNA	Cancer
mmu-let-7a-1-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-let-7a-1-3p inhibitor mmu-let-7a-1-3p inhibitor

HY-RI00014

hsa-let-7i-5p inhibitor	MicroRNA	Cancer
hsa-let-7i-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7i-5p inhibitor hsa-let-7i-5p inhibitor

HY-RI00006

hsa-let-7c-3p inhibitor	MicroRNA	Cancer
hsa-let-7c-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7c-3p inhibitor hsa-let-7c-3p inhibitor

HY-RI00007

hsa-let-7c-5p inhibitor	MicroRNA	Cancer
hsa-let-7c-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7c-5p inhibitor hsa-let-7c-5p inhibitor

HY-R00008A

hsa-let-7d-3p agomir	MicroRNA
hsa-let-7d-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7d-3p agomir hsa-let-7d-3p agomir

HY-R00002A

hsa-let-7a-3p agomir	MicroRNA
hsa-let-7a-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7a-3p agomir hsa-let-7a-3p agomir

HY-R02558A

mmu-let-7a-2-3p agomir	MicroRNA	Cancer
mmu-let-7a-2-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-let-7a-2-3p agomir mmu-let-7a-2-3p agomir

HY-R00012A

hsa-let-7g-5p agomir	MicroRNA
hsa-let-7g-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7g-5p agomir hsa-let-7g-5p agomir

HY-R00006A

hsa-let-7c-3p agomir	MicroRNA
hsa-let-7c-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7c-3p agomir hsa-let-7c-3p agomir

HY-R00001A

hsa-let-7a-2-3p agomir	MicroRNA
hsa-let-7a-2-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7a-2-3p agomir hsa-let-7a-2-3p agomir

HY-R00005A

hsa-let-7b-5p agomir	MicroRNA
hsa-let-7b-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7b-5p agomir hsa-let-7b-5p agomir

HY-R00003A

hsa-let-7a-5p agomir	MicroRNA
hsa-let-7a-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7a-5p agomir hsa-let-7a-5p agomir

HY-R04205A

rno-let-7f-1-3p agomir	MicroRNA	Cancer
rno-let-7f-1-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

rno-let-7f-1-3p agomir rno-let-7f-1-3p agomir

HY-RI02560A

mmu-let-7j antagomir	MicroRNA	Cancer
mmu-let-7j antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-let-7j antagomir mmu-let-7j antagomir

HY-RI02561A

mmu-let-7k antagomir	MicroRNA	Cancer
mmu-let-7k antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-let-7k antagomir mmu-let-7k antagomir

HY-RI00014A

hsa-let-7i-5p antagomir	MicroRNA	Cancer
hsa-let-7i-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7i-5p antagomir hsa-let-7i-5p antagomir

HY-RI00005A

hsa-let-7b-5p antagomir	MicroRNA	Cancer
hsa-let-7b-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7b-5p antagomir hsa-let-7b-5p antagomir

HY-RI00006A

hsa-let-7c-3p antagomir	MicroRNA	Cancer
hsa-let-7c-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7c-3p antagomir hsa-let-7c-3p antagomir

HY-RI00011A

hsa-let-7f-2-3p antagomir	MicroRNA	Cancer
hsa-let-7f-2-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7f-2-3p antagomir hsa-let-7f-2-3p antagomir

HY-RI00001A

hsa-let-7a-2-3p antagomir	MicroRNA	Cancer
hsa-let-7a-2-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7a-2-3p antagomir hsa-let-7a-2-3p antagomir

HY-RI00008A

hsa-let-7d-3p antagomir	MicroRNA	Cancer
hsa-let-7d-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7d-3p antagomir hsa-let-7d-3p antagomir

HY-RI00002A

hsa-let-7a-3p antagomir	MicroRNA	Cancer
hsa-let-7a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7a-3p antagomir hsa-let-7a-3p antagomir

Cat. No.	Product Name		Classification