2 Results for "

luspatercept

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "luspatercept" in MCE Product Catalog:

5
Luspatercept
Luspatercept
0 Images
5 Cited Publications
Cat. No.: HY-P99720
CAS No.: 1373715-00-4
Synonyms: ACE-536; luspatercept–aamt

Target:  

TGF-beta/Smad

Research Areas:  

Cardiovascular Disease

Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia .
loading...
    loading...
View All Sizes
Luspatercept (mIgG2a)
Luspatercept (mIgG2a)
0 Images
Cat. No.: HY-P99720A
CAS No.: 1373715-00-4
Synonyms: RAP-536

Target:  

TGF-beta/Smad

Research Areas:  

Metabolic Disease

Luspatercept (mIgG2a) (RAP-536) is a fusion protein, consisting of a modified extracellular domain of human ActRIIB linked to the murine IgG2a Fc domain. Luspatercept (mIgG2a) inhibits Smad2/3 signaling, promotes differentiation of late-stage erythroid precursors and mitigates ineffective erythropoiesis (IE) in murine β-thalassemia. Luspatercept (mIgG2a) reduces anemia, α-globin aggregates, hemolysis, and disease complications of IE such as iron overload, splenomegaly, and bone defects .
loading...
    loading...
View All Sizes
Assay Types