SPRED2 - sprouty related EVH1 domain containing 2 Gene
Also Known as NS14; Spred-2
Species: Homo sapiens
About SPRED2
This gene has 8 transcripts (splice variants), 278 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 9.3), fat (RPKM 9.2) and 25 other tissues.
Summary
SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
SPRED2 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001128210.2 | NP_001121682.1 | sprouty-related, EVH1 domain-containing protein 2 isoform b |
| NM_181784.3 | NP_861449.2 | sprouty-related, EVH1 domain-containing protein 2 isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
19822672 | GOA |
| enables protein kinase binding |
IPI
IPI: Inferred from physical interaction
|
20736167 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in negative regulation of peptidyl-threonine phosphorylation |
IMP
IMP: Inferred from mutant phenotype
|
20736167 | GOA |
SPRED2 Protein Structure
WH1: WH1 domain (14 - 118)
Sprouty: Sprouty protein (Spry) (306 - 411)
- 0
- 100
- 200
- 300
- 400
- 418 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
sprouty-related, EVH1 domain-containing protein 2 |
|
SPRED2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SPRED2 | Q7Z698 | KRTAP12-2 | Homo sapiens | P59991 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | KRTAP12-2 | Homo sapiens | P59991 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | RPS6KA3 | Homo sapiens | P51812 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | RPS6KA3 | Homo sapiens | P51812 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | RPS6KA3 | Homo sapiens | P51812 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | RPS6KA3 | Homo sapiens | P51812 | 28514442 | |
|
Intra
|
SPRED2 | Q7Z698 | NEK7 | Homo sapiens | Q8TDX7 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | NEK7 | Homo sapiens | Q8TDX7 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | NEK7 | Homo sapiens | Q8TDX7 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | DNM2 | Homo sapiens | P50570-2 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | DNM2 | Homo sapiens | P50570-2 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | DNM2 | Homo sapiens | P50570-2 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | KIF1B | Homo sapiens | O60333-2 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | KIF1B | Homo sapiens | O60333-2 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | KIF1B | Homo sapiens | O60333-2 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | DMWD | Homo sapiens | G5E9A7 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | DMWD | Homo sapiens | G5E9A7 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | DMWD | Homo sapiens | G5E9A7 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | KPRP | Homo sapiens | Q5T749 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | KPRP | Homo sapiens | Q5T749 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | LCE2B | Homo sapiens | O14633 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | LCE2B | Homo sapiens | O14633 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | LCE5A | Homo sapiens | Q5TCM9 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | LCE5A | Homo sapiens | Q5TCM9 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | ZNF837 | Homo sapiens | Q96EG3 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | ZNF837 | Homo sapiens | Q96EG3 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | ZNF837 | Homo sapiens | Q96EG3 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | LCE1C | Homo sapiens | Q5T751 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | LCE1C | Homo sapiens | Q5T751 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | NDUFB7 | Homo sapiens | P17568 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | NDUFB7 | Homo sapiens | P17568 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | KRTAP2-4 | Homo sapiens | Q9BYR9 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | KRTAP2-4 | Homo sapiens | Q9BYR9 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | KRTAP2-4 | Homo sapiens | Q9BYR9 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | ZNF575 | Homo sapiens | Q86XF7 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | GLE1 | Homo sapiens | Q53GS7 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | GLE1 | Homo sapiens | Q53GS7 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | GLE1 | Homo sapiens | Q53GS7 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | TSNAX | Homo sapiens | Q99598 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | TSNAX | Homo sapiens | Q99598 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | TSNAX | Homo sapiens | Q99598 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | APBB2 | Homo sapiens | Q92870-2 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | APBB2 | Homo sapiens | Q92870-2 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | APBB2 | Homo sapiens | Q92870-2 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | KCNIP1 | Homo sapiens | Q9NZI2-2 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | KCNIP1 | Homo sapiens | Q9NZI2-2 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | KCNIP1 | Homo sapiens | Q9NZI2-2 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | CHAT | Homo sapiens | P28329-3 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | CHAT | Homo sapiens | P28329-3 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | CHAT | Homo sapiens | P28329-3 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | TOP3B | Homo sapiens | O95985 | 25416956 | |
|
Intra
|
SPRED2 | Q7Z698 | TOP3B | Homo sapiens | O95985 | 29892012 | |
|
Intra
|
SPRED2 | Q7Z698 | RNF11 | Homo sapiens | Q9Y3C5 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | RNF11 | Homo sapiens | Q9Y3C5 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | RNF11 | Homo sapiens | Q9Y3C5 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | RBM48 | Homo sapiens | Q5RL73 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | RBM48 | Homo sapiens | Q5RL73 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | PMP22 | Homo sapiens | A0A6Q8PF08 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | PMP22 | Homo sapiens | A0A6Q8PF08 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | PMP22 | Homo sapiens | A0A6Q8PF08 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | ZDHHC17 | Homo sapiens | Q8IUH5 | 33961781 | |
|
Intra
|
SPRED2 | Q7Z698 | ZDHHC17 | Homo sapiens | Q8IUH5 | 24705354 | |
|
Intra
|
SPRED2 | Q7Z698 | ZDHHC17 | Homo sapiens | Q8IUH5 | 24705354 | |
|
Intra
|
SPRED2 | Q7Z698 | NDUFV2 | Homo sapiens | P19404 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | NDUFV2 | Homo sapiens | P19404 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | NDUFV2 | Homo sapiens | P19404 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | RPS6KA6 | Homo sapiens | Q9UK32 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | MDFI | Homo sapiens | Q99750 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | MDFI | Homo sapiens | Q99750 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | MDFI | Homo sapiens | Q99750 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | ZNF417 | Homo sapiens | Q8TAU3 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | VSNL1 | Homo sapiens | P62760 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | VSNL1 | Homo sapiens | P62760 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | SPG21 | Homo sapiens | Q9NZD8 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | SPG21 | Homo sapiens | Q9NZD8 | 31515488 | |
|
Intra
|
SPRED2 | Q7Z698 | SPG21 | Homo sapiens | Q9NZD8 | 25416956 | |
|
Intra
|
SPRED2 | Q7Z698 | SPG21 | Homo sapiens | Q9NZD8 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | SPG21 | Homo sapiens | Q9NZD8 | 25416956 | |
|
Intra
|
SPRED2 | Q7Z698 | SPG21 | Homo sapiens | Q9NZD8 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | ZNF414 | Homo sapiens | Q96IQ9 | 32296183 | |
|
Intra
|
SPRED2 | Q7Z698 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | PRPS1 | Homo sapiens | P60891 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | PRPS1 | Homo sapiens | P60891 | 32814053 | |
|
Intra
|
SPRED2 | Q7Z698 | PRPS1 | Homo sapiens | P60891 | 32814053 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Noonan Syndrome 14 |
|
|
| Noonan Syndrome 1 |
|
|
| Pseudo-Turner Syndrome |
|
|
| Legius Syndrome |
|
|
| Rasopathy |
|
|
| Retinitis Pigmentosa |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | SPRED2 | VGNC | VGNC:106225 |
| Canis familiaris | SPRED2 | VGNC | VGNC:46763 |
| Bos taurus | SPRED2 | VGNC | VGNC:58416 |
| Mus musculus | SPRED2 | MGD | MGI:2150019 |
| Rattus norvegicus | SPRED2 | RGD | RGD:1309304 |
| Felis catus | SPRED2 | VGNC | VGNC:65647 |
| Others | SPRED2 | NCBI |