LLGL2 - LLGL scribble cell polarity complex component 2 Gene

Also Known as HGL; LGL2; Hugl-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3993

About LLGL2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,525,002-75,575,209 (from NCBI)

This gene has 22 transcripts (splice variants), 209 orthologues and 3 paralogues. Broad expression in stomach (RPKM 24.5), colon (RPKM 24.0) and 22 other tissues.

Summary

The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

LLGL2 Products (3)

mRNA Protein Name
NM_001015002.2 NP_001015002.1 LLGL scribble cell polarity complex component 2 isoform b
NM_001031803.2 NP_001026973.1 LLGL scribble cell polarity complex component 2 isoform c
NM_004524.3 NP_004515.2 LLGL scribble cell polarity complex component 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
12725730 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12725730 GOA
Biological Process GO Annotation Evidence References Source
involved in L-leucine transport IMP
IMP: Inferred from mutant phenotype
30996345 GOA
involved in regulation of establishment or maintenance of cell polarity IDA
IDA: Inferred from direct assay
12725730 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15632202 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LLGL2 Protein Structure

LLGL

LLGL: LLGL2 (269 - 372)

WD40

WD40: WD domain, G-beta repeat (428 - 451)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1020 a.a.
Protein Preferred Names Protein Names

LLGL scribble cell polarity complex component 2

  • LLGL2, scribble cell polarity complex component

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07701 LLGL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22611 Llgl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29126 Llgl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LLGL2 VGNC VGNC:68061
Canis familiaris LLGL2 VGNC VGNC:42705
Rattus norvegicus LLGL2 RGD RGD:1560307
Mus musculus LLGL2 MGD MGI:1918843
Macaca mulatta LLGL2 VGNC VGNC:99166
Bos taurus LLGL2 VGNC VGNC:30916
Others LLGL2 NCBI