MTG2 - mitochondrial ribosome associated GTPase 2 Gene

Also Known as ObgH1; GTPBP5; dJ1005F21.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26164

About MTG2

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,183,028-62,203,568 (from NCBI)

This gene has 10 transcripts (splice variants), 203 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 3.6), skin (RPKM 3.3) and 25 other tissues.

Summary

Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]

MTG2 Products (3)

mRNA Protein Name
NM_001384347.1 NP_001371276.1 mitochondrial ribosome-associated GTPase 2 isoform 1
NM_001384348.1 NP_001371277.1 mitochondrial ribosome-associated GTPase 2 isoform 3
NM_015666.4 NP_056481.1 mitochondrial ribosome-associated GTPase 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IDA
IDA: Inferred from direct assay
23396448 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of mitochondrial translation IMP
IMP: Inferred from mutant phenotype
23396448 GOA
involved in regulation of respiratory system process IMP
IMP: Inferred from mutant phenotype
23396448 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
23396448 GOA
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
23396448 GOA
located in mitochondrial ribosome IDA
IDA: Inferred from direct assay
23396448 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTG2 Protein Structure

GTP1_OBG

GTP1_OBG: GTP1/OBG (72 - 223)

MMR_HSR1

MMR_HSR1: 50S ribosome-binding GTPase (227 - 346)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

mitochondrial ribosome-associated GTPase 2

  • GTP binding protein 5 (putative)

Related Diseases

Diseases Alias
Endocervicitis
Bone Osteosarcoma

  • Osteosarcoma Of Bone

  • Primary Osteosarcoma Of Bone
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08773 MTG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MTG2 MGD MGI:106565
Bos taurus MTG2 VGNC VGNC:31729
Rattus norvegicus MTG2 RGD RGD:1359243
Canis familiaris MTG2 VGNC VGNC:43471
Macaca mulatta MTG2 VGNC VGNC:74972
Felis catus MTG2 VGNC VGNC:63649
Others MTG2 NCBI