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TMEM208 - transmembrane protein 208 Gene

Also Known as hSND2; HSPC171

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29100

About TMEM208

This gene has 12 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in adrenal (RPKM 19.0), kidney (RPKM 17.8) and 25 other tissues.

Summary

This gene encodes a highly conserved protein which is localized in the endoplasmic reticulum (ER). The protein is linked to Autophagy and ER stress. Knockdown of this gene increased Autophagy and triggered ER stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

TMEM208 Products (2)

mRNA	Protein	Name
NM_001318217.2	NP_001305146.1	transmembrane protein 208 isoform 2
NM_014187.4	NP_054906.2	transmembrane protein 208 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	38381787	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM208 Protein Structure

DUF788

0
100
173 a.a.

Protein Preferred Names	Protein Names
transmembrane protein 208	SRP-independent targeting 2 homolog

TMEM208 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TMEM208	Q9BTX3	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	REEP2	Homo sapiens	Q9BRK0	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	REEP2	Homo sapiens	Q9BRK0	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	NDRG4	Homo sapiens	Q9ULP0-2	Validated Y2H	32296183
Intra	TMEM208	Q9BTX3	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	SCARA5	Homo sapiens	Q6ZMJ2-2	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	SCARA5	Homo sapiens	Q6ZMJ2-2	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	GPRC5D	Homo sapiens	Q9NZD1	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	GPRC5D	Homo sapiens	Q9NZD1	Validated Y2H	32296183
Intra	TMEM208	Q9BTX3	GPRC5D	Homo sapiens	Q9NZD1	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	SLC7A8	Homo sapiens	Q9UHI5	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	SLC7A8	Homo sapiens	Q9UHI5	Validated Y2H	32296183
Intra	TMEM208	Q9BTX3	SLC7A8	Homo sapiens	Q9UHI5	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	C10orf67	Homo sapiens	Q8IYJ2-2	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	C10orf67	Homo sapiens	Q8IYJ2-2	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	TMEM208	Q9BTX3	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	TMEM208	Q9BTX3	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	TMEM208	Q9BTX3	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	TMEM208	Q9BTX3	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	TMEM208	Q9BTX3	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 5	MRD5 Autosomal Dominant Non-Syndromic Intellectual Disability 5 Intellectual Disability, Autosomal Dominant 5 Mental Retardation, Autosomal Dominant 5 Autosomal Dominant Intellectual Developmental Disorder 5 Syngap1-Related Non-Syndromic Intellectual Disability Autosomal Dominant Intellectual Disability 5 Syngap1 Syndrome Syngap1-Related Nsid Syngap1 Gene Mutation Linked To Intellectual Disability, Schizophrenia And Autism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14695	TMEM208 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TMEM208	MGD	MGI:1913570
Canis familiaris	TMEM208	VGNC	VGNC:47527
Felis catus	TMEM208	VGNC	VGNC:66307
Rattus norvegicus	TMEM208	RGD	RGD:1560953
Bos taurus	TMEM208	VGNC	VGNC:36030
Macaca mulatta	TMEM208	VGNC	VGNC:79469
Others	TMEM208	NCBI