NDFIP1 - Nedd4 family interacting protein 1 Gene

Also Known as N4WBP5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80762

About NDFIP1

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:142,108,779-142,154,440 (from NCBI)

This gene has 4 transcripts (splice variants), 280 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 106.7), thyroid (RPKM 68.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]

NDFIP1 Products (1)

mRNA Protein Name
NM_030571.4 NP_085048.1 NEDD4 family-interacting protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18776082 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
18776082 GOA
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18776082 GOA
involved in negative regulation of protein transport IMP
IMP: Inferred from mutant phenotype
18776082 GOA
involved in negative regulation of transporter activity IMP
IMP: Inferred from mutant phenotype
18776082 GOA
involved in positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
25631046 GOA
involved in positive regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
18776082 GOA
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18776082 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDFIP1 Protein Structure

DUF2370

DUF2370: Protein of unknown function (DUF2370) (56 - 167)

DUF2370

DUF2370: Protein of unknown function (DUF2370) (175 - 212)

  • 0
  • 100
  • 200
  • 221 a.a.
Protein Preferred Names Protein Names

NEDD4 family-interacting protein 1

  • Nedd4 WW domain-binding protein 5

NDFIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NDFIP1 Q9BT67 SLC11A2 Homo sapiens P49281
Anti Bait CoIP
19706893
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Congenital Myasthenic Syndrome 7

  • Cms7

  • Congenital Myasthenic Syndrome 7 Presynaptic

  • Myasthenic Syndrome, Congenital, Type 7, Presynaptic
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09108 NDFIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NDFIP1 VGNC VGNC:63750
Canis familiaris NDFIP1 VGNC VGNC:43673
Rattus norvegicus NDFIP1 RGD RGD:1310053
Bos taurus NDFIP1 VGNC VGNC:31934
Mus musculus NDFIP1 MGD MGI:1929601
Macaca mulatta NDFIP1 VGNC VGNC:74979
Others NDFIP1 NCBI