CPN1 - carboxypeptidase N subunit 1 Gene

Also Known as CPN; SCPN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1369

About CPN1

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:100,042,193-100,081,869 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues, 7 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 18.6).

Summary

Carboxypeptidase N is a plasma metallo-protease that cleaves basic Amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from Carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]

CPN1 Products (1)

mRNA Protein Name
NM_001308.3 NP_001299.1 carboxypeptidase N catalytic chain precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPN1 Protein Structure

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (34 - 329)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (342 - 416)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
Protein Preferred Names Protein Names

carboxypeptidase N catalytic chain

  • anaphylatoxin inactivator

CPN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CPN1 P15169 PRKCA Homo sapiens P17252
Y2H Pooling
32814053
Intra
CPN1 P15169 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
CPN1 P15169 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
CPN1 P15169 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Carboxypeptidase N Deficiency

  • Anaphylotoxin Inactivator Deficiency

  • Deficiency Of Carboxypeptidase B

  • CPND
Chronic Urticaria

  • Urticaria Chronic

  • Chronic Spontaneous Urticaria

  • Chronic Ordinary Urticaria
Angioedema

  • Angioneurotic Oedema

  • Quincke'S Edema

  • Angioneurotic Edema

  • Giant Urticaria
Urticaria

  • Nettle Rash

  • Hives

  • Wheal

  • Urticaria Nos
Inclusion Conjunctivitis

  • Chlamydial Conjunctivitis

  • Inclusion Blennorrhoea

  • Paratrachoma

  • Adult Inclusion Conjunctivitis

  • Inclusion Blenorrhea

  • Conjunctivitis, Inclusion

  • Neonatal Chlamydial Conjunctivitis

  • Inclusion Conjunctivitis Of The Adult

  • Chronic Conjunctivitis Due To Chlamydia Trachomatis

  • Inclusion Conjunctivitis Due To Chlamydia Trachomatis

  • Acute Follicular Conjunctivitis, Chlamydial

  • Adult Chlamydial Keratoconjunctivitis
Lymphogranuloma Venereum

  • Climatic Or Tropical Bubo

  • Durand-Nicolas-Favre Disease

  • Lymphogranuloma Inguinale

  • Poradenitis Inguinale

  • Strumous Bubo

  • Lgv
Granuloma Inguinale

  • Donovanosis

  • Pudendal Ulcer

  • Granuloma Inguinale Tropicum

  • Granuloma Pudendi Tropicum
Ornithosis

  • Psittacosis

  • Chlamydial Pneumonia

  • Chlamydia Psittaci Infection

  • Chlamydia Psittaci
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03101 CPN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03103 CPNE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03435 CYP11B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17315 Cyp11b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20260 Cpn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26768 Cpn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CPN1 MGD MGI:2135874
Rattus norvegicus CPN1 RGD RGD:70931
Canis familiaris CPN1 VGNC VGNC:39558
Macaca mulatta CPN1 VGNC VGNC:71462
Felis catus CPN1 VGNC VGNC:61127
Bos taurus CPN1 VGNC VGNC:27656
Others CPN1 NCBI