EPN2 - epsin 2 Gene

Also Known as EHB21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22905

About EPN2

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,237,366-19,336,715 (from NCBI)

This gene has 27 transcripts (splice variants), 207 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 30.1), skin (RPKM 20.7) and 25 other tissues.

Summary

This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

EPN2 Products (3)

mRNA Protein Name
NM_001102664.2 NP_001096134.1 epsin-2 isoform c
NM_014964.5 NP_055779.2 epsin-2 isoform b
NM_148921.4 NP_683723.2 epsin-2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18199683 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
28717225 GOA
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
28717225 GOA
involved in positive regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
28717225 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPN2 Protein Structure

ENTH

ENTH: ENTH domain (17 - 140)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 641 a.a.
Protein Preferred Names Protein Names

epsin-2

  • EPS-15-interacting protein 2

EPN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EPN2 O95208 SYNGAP1 Homo sapiens Q96PV0
Anti Bait CoIP
37207277
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Adult Spinal Cord Ependymoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04444 EPN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EPN2 VGNC VGNC:72070
Canis familiaris EPN2 VGNC VGNC:40420
Bos taurus EPN2 VGNC VGNC:28547
Rattus norvegicus EPN2 RGD RGD:619773
Felis catus EPN2 VGNC VGNC:61913
Mus musculus EPN2 MGD MGI:1333766
Others EPN2 NCBI