EPN2 - epsin 2 Gene

Homo sapiens

Also known as EHB21

Gene ID: 22905 | Gene type: protein coding

About EPN2

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,237,366-19,336,715 (from NCBI)

This gene has 27 transcripts (splice variants), 207 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 30.1), skin (RPKM 20.7) and 25 other tissues.

Summary

This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

EPN2 Products(3)

mRNA	Protein	Name
NM_001102664.2	NP_001096134.1	epsin-2 isoform c
NM_014964.5	NP_055779.2	epsin-2 isoform b
NM_148921.4	NP_683723.2	epsin-2 isoform a

EPN2 Protein Structure

ENTH

0
100
200
300
400
500
600
641 a.a.

Protein Preferred Names

Protein Names

epsin-2

EPS-15-interacting protein 2

Related Diseases

Diseases

Alias

Adult Spinal Cord Ependymoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04444	EPN2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EPN2	VGNC	VGNC:72070
Canis familiaris	EPN2	VGNC	VGNC:40420
Bos taurus	EPN2	VGNC	VGNC:28547
Rattus norvegicus	EPN2	RGD	RGD:619773
Felis catus	EPN2	VGNC	VGNC:61913
Mus musculus	EPN2	MGD	MGI:1333766