CRTAM - cytotoxic and regulatory T cell molecule Gene

Also Known as CD355

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56253

About CRTAM

Cytogenetic location: 11q24.1 Genomic coordinates (GRCh38): 11:122,838,500-122,872,643 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and 14 paralogues. Biased expression in lymph node (RPKM 4.2), spleen (RPKM 1.7) and 11 other tissues.

Summary

The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]

CRTAM Products (2)

mRNA Protein Name
NM_001304782.2 NP_001291711.1 cytotoxic and regulatory T-cell molecule isoform 2 precursor
NM_019604.4 NP_062550.2 cytotoxic and regulatory T-cell molecule isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
23583034 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23871486 GOA
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
15811952 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
15811952 GOA
NOT involved in activated T cell proliferation IDA
IDA: Inferred from direct assay
15811952 GOA
involved in cell recognition IDA
IDA: Inferred from direct assay
15811952 GOA
involved in detection of stimulus IDA
IDA: Inferred from direct assay
15811952 GOA
involved in detection of tumor cell IDA
IDA: Inferred from direct assay
15811952 GOA
involved in positive regulation of cytokine production IDA
IDA: Inferred from direct assay
15811952 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
15811952 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA
IDA: Inferred from direct assay
15811952 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
15811952 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRTAM Protein Structure

V-set

V-set: Immunoglobulin V-set domain (20 - 113)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (129 - 206)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
Protein Preferred Names Protein Names

cytotoxic and regulatory T-cell molecule

  • class-I MHC-restricted T-cell-associated molecule

Recombinant CRTAM Proteins

Cat. No. Product Name Accession Purity
HY-P7855 CRTAM/CD355 Protein, Human (HEK293, His) O95727-1 (S18-S286) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03198 CRTAM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17420 Crtam Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23874 Crtam Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CRTAM VGNC VGNC:84883
Mus musculus CRTAM MGD MGI:1859822
Bos taurus CRTAM VGNC VGNC:27726
Canis familiaris CRTAM VGNC VGNC:39630
Felis catus CRTAM VGNC VGNC:61190
Rattus norvegicus CRTAM RGD RGD:1304602
Others CRTAM NCBI