PTGS1 - prostaglandin-endoperoxide synthase 1 Gene

Also Known as COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5742

About PTGS1

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:122,370,533-122,395,703 (from NCBI)

This gene has 10 transcripts (splice variants), 256 orthologues and 1 paralogue. Biased expression in skin (RPKM 36.8), esophagus (RPKM 21.4) and 12 other tissues.

Summary

This is one of two genes encoding similar Enzymes that catalyze the conversion of arachidonate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2021]

PTGS1 Products (7)

mRNA	Protein	Name
NM_000962.4	NP_000953.2	prostaglandin G/H synthase 1 isoform 1 precursor
NM_001271164.2	NP_001258093.1	prostaglandin G/H synthase 1 isoform 3 precursor
NM_001271165.2	NP_001258094.1	prostaglandin G/H synthase 1 isoform 4
NM_001271166.2	NP_001258095.1	prostaglandin G/H synthase 1 isoform 5
NM_001271367.2	NP_001258296.1	prostaglandin G/H synthase 1 isoform 5
NM_001271368.2	NP_001258297.1	prostaglandin G/H synthase 1 isoform 6
NM_080591.3	NP_542158.1	prostaglandin G/H synthase 1 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables prostaglandin-endoperoxide synthase activity	IDA IDA: Inferred from direct assay	1380156	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cyclooxygenase pathway	IDA IDA: Inferred from direct assay	1380156	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12355421	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGS1 Protein Structure

An_peroxidase

0
100
200
300
400
500
599 a.a.

Protein Preferred Names	Protein Names
prostaglandin G/H synthase 1	PGH synthase 1

PTGS1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82792	Cyclooxygenase 1 Antibody (YA2537)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P82792A	Cyclooxygenase 1 Antibody (YA2537)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Gastric Ulcer	Stomach Ulcer Acute Gastric Ulcer With Haemorrhage And Perforation Acute Gastric Ulcer With Hemorrhage And Obstruction Acute Gastric Ulcer With Hemorrhage And Perforation Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction Acute Gastric Ulcer With Hemorrhage, With Obstruction Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction Acute Gastric Ulcer With Perforation Acute Gastric Ulcer With Perforation And Obstruction Acute Gastric Ulcer With Perforation, With Obstruction Acute Gastric Ulcer Without Hemorrhage And Without Perforation Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction Bleeding Acute Gastric Ulcer Chronic Gastric Ulcer Without Hemorrhage And Without Perforation Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction Gastric Ulcers Cushings Ulcer Cushing'S Ulcer Of Stomach Peptic Ulcer Of Stomach Mucosal Defect Of The Stomach
Urticaria	Nettle Rash Hives Wheal Urticaria Nos
Dirofilariasis	Dirofilaria Infectious Disease Infection By Dirofilaria
Chronic Cystitis
Familial Adenomatous Polyposis	Adenomatous Polyposis Coli Fap Familial Polyposis Coli Familial Multiple Polyposis Syndrome Adenomatous Polyposis Of The Colon Familial Intestinal Polyposis Fpc Familial Adenomatous Polyposis Of The Colon Familial Multiple Polyposis Familial Polyposis Of The Colon Hereditary Polyposis Coli Polyposis, Adenomatous Intestinal Adenomatous Familial Polyposis Adenomatous Familial Polyposis Syndrome Myh-Associated Polyposis Colorectal Adenomatous Polyposis Adenomatous Polyposis, Familial Mutyh-Associate Polyposis
Peptic Ulcer Disease	Peptic Ulcer Acute Peptic Ulcer With Hemorrhage Acute Peptic Ulcer With Hemorrhage And Perforation Acute Peptic Ulcer Without Hemorrhage And Without Perforation
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Angioedema	Angioneurotic Oedema Quincke'S Edema Angioneurotic Edema Giant Urticaria
Osteoarthritis	Osteoarthrosis Degenerative Joint Disease Hypertrophic Arthritis Arthropathy Degenerative Polyarthritis Degenerative Arthritis Osteoarthrosis And Allied Disorder Arthritis, Degenerative Oa Osteoarthritis Deformans Osteoarthrosis Deformans Kashin-Beck Disease
Gastritis	Acute Gastric Mucosal Erosion Erosive Gastritis Erosive Gastropathy Gastritis Erosive Idiopathic Erosive/Hemorrhagic Gastritis Inflammation Of Gastric Mucosa Gastroduodenitis Gastritis Nos Noninfectious Gastroenteritis Nonbacterial Gastroenteritis Of Infant Acute Gastric Infection Acute Simple Gastritis Chronic Antral Gastritis Chronic Fundal Gastritis Chronic Simple Gastritis Acute Gastroduodenitis Acute Antral Gastritis Acute Erosive Gastritis Bile Reflux Gastritis Gastritis Due To Biliary Reflux
Ureteral Obstruction
Bleeding Disorder, Platelet-Type, 12	BDPLT12 Prostaglandin-Endoperoxide Synthase 1 Deficiency, Platelet Pghs1 Deficiency Platelet Cyclooxygenase 1 Deficiency Platelet Cox1 Deficiency Platelet-Type Bleeding Disorder 12 Platelet Prostaglandin-Endoperoxide Synthase 1 Deficiency
Rhinitis	Runny Nose
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Aspirin Allergy	Acetylsalicylic Acid Allergy Asa Allergy
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Aspirin-Induced Respiratory Disease	Aspirin-Sensitive Asthma
Thrombosis	Thrombosis Of Blood Vessel
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Chronic Urticaria	Urticaria Chronic Chronic Spontaneous Urticaria Chronic Ordinary Urticaria
Portal Hypertension	Hypertension, Portal Hypertension Portal Pht - [Portal Hypertension] Portal Htn
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Kidney Papillary Necrosis	Necrotizing Renal Papillitis Papillary Necrosis Renal Papillitis Necrotizing
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Stomach Disease	Gastropathy Stomach Diseases Gastric Disease Stomach Disorder Gastric Disorder Stomach Disorders
Constipation
Colitis
Asthma, Nasal Polyps, And Aspirin Intolerance	Asthma And Nasal Polyps Asa Triad Asthma, Aspirin-Induced, Susceptibility To Asthma, Aspirin-Induced Asthma, With Nasal Polyps And Aspirin Intolerance ANPAI Aia Aspirin-Intolerant Asthma Asthma Aspirin-Induced Nasal Polyps Asthma And Aspirin Sensitivity Samter Triad Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps
Proteasome-Associated Autoinflammatory Syndrome 1	Jmp Syndrome Nakajo-Nishimura Syndrome Nkjo Autoinflammation, Lipodystrophy, And Dermatosis Syndrome Proteasome-Associated Autoinflammatory Syndrome 1 And Digenic Forms Nakajo Syndrome PRAAS1 Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy And Elevated Temperature Syndrome Candle Joint Contractures, Muscular Atrophy, Microcytic Anemia, And Panniculitis-Induced Lipodystrophy Aldd Inflammation Joint Contractures - Muscle Atrophy - Microcytic Anemia - Panniculitis-Induced Lipodystrophy Nakajo Nishimura Syndrome Amyotrophy Fat Tissue Anomaly Japanese Autoinflammatory Syndrome With Lipodystrophy Jasl Joint Contractures Muscular Atrophy Microcytic Anemia And Panniculitis-Induced Lipodystrophy Nns Nodular Erythema With Digital Changes Secondary Hypertrophic Osteoperiostosis With Pernio
Active Peptic Ulcer Disease	Gi Bleeding Active Peptic Ulcer Gastrointestinal Hemorrhage
Phenytoin Allergy	Dilantin Allergy
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Respiratory Disease Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Trichothiodystrophy 7, Nonphotosensitive	TTD7 Nonphotosensitive Trichothiodystrophy 7 Trichothiodystrophy 7, Non-Photosensitive
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Dicrocoeliasis	Disease Due To Dicrocoeliidae Lancet Fluke Infection Dicroceliosis Lancet Fluke Disease Lancet Fluke Infestation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Diabetes Mellitus	Diabetes
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11392	PTGS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19231	Ptgs1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25720	Ptgs1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PTGS1	VGNC	VGNC:69147
Rattus norvegicus	PTGS1	RGD	RGD:3439
Bos taurus	PTGS1	VGNC	VGNC:33511
Mus musculus	PTGS1	MGD	MGI:97797
Canis familiaris	PTGS1	VGNC	VGNC:45151
Macaca mulatta	PTGS1	VGNC	VGNC:76588
Others	PTGS1	NCBI