HECTD3 - HECT domain E3 ubiquitin protein ligase 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79654

About HECTD3

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,002,548-45,011,324 (from NCBI)

This gene has 7 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in duodenum (RPKM 25.9), small intestine (RPKM 22.6) and 25 other tissues.

Summary

The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]

HECTD3 Products (1)

mRNA Protein Name
NM_024602.6 NP_078878.3 E3 ubiquitin-protein ligase HECTD3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18194665 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
18194665 GOA
Biological Process GO Annotation Evidence References Source
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
18194665 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HECTD3 Protein Structure

ANAPC10

ANAPC10: Anaphase-promoting complex, subunit 10 (APC10) (247 - 389)

HECT

HECT: HECT-domain (ubiquitin-transferase) (583 - 848)

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  • 200
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  • 800
  • 861 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase HECTD3

  • HECT domain containing E3 ubiquitin protein ligase 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06109 HECTD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20555 Hectd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27064 Hectd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HECTD3 VGNC VGNC:29802
Mus musculus HECTD3 MGD MGI:1923858
Rattus norvegicus HECTD3 RGD RGD:1309823
Macaca mulatta HECTD3 VGNC VGNC:73240
Felis catus HECTD3 VGNC VGNC:62784
Others HECTD3 NCBI