MND1 - meiotic nuclear divisions 1 Gene

Also Known as GAJ

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84057

About MND1

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:153,344,649-153,415,118 (from NCBI)

This gene has 6 transcripts (splice variants) and 214 orthologues. Broad expression in testis (RPKM 3.9), lymph node (RPKM 2.6) and 15 other tissues.

Summary

The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]

MND1 Products (2)

mRNA Protein Name
NM_001253861.1 NP_001240790.1 meiotic nuclear division protein 1 homolog isoform 2
NM_032117.4 NP_115493.1 meiotic nuclear division protein 1 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16407260 GOA
Biological Process GO Annotation Evidence References Source
involved in homologous chromosome pairing at meiosis IDA
IDA: Inferred from direct assay
16407260 GOA
involved in reciprocal meiotic recombination IDA
IDA: Inferred from direct assay
16407260 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MND1 Protein Structure

Mnd1

Mnd1: Mnd1 family (16 - 203)

  • 0
  • 100
  • 205 a.a.
Protein Preferred Names Protein Names

meiotic nuclear division protein 1 homolog

  • homolog of yeast MND1

MND1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MND1 Q9BWT6 PSMC3IP Homo sapiens Q9P2W1
Anti Tag CoIP
26496610
Intra
MND1 Q9BWT6 PSMC3IP Homo sapiens Q9P2W1
Anti Tag CoIP
33961781
Intra
MND1 Q9BWT6 PSMC3IP Homo sapiens Q9P2W1
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08567 MND1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19147 Mnd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MND1 VGNC VGNC:31538
Mus musculus MND1 MGD MGI:1924165
Rattus norvegicus MND1 RGD RGD:1309007
Canis familiaris MND1 VGNC VGNC:43296
Felis catus MND1 VGNC VGNC:63542
Others MND1 NCBI