DDI2 - DNA damage inducible 1 homolog 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84301

About DDI2

This gene has 6 transcripts (splice variants), 164 orthologues and 4 paralogues. Ubiquitous expression in esophagus (RPKM 7.7), kidney (RPKM 5.8) and 25 other tissues.

Summary

Enables aspartic-type endopeptidase activity; identical protein binding activity; and ubiquitin binding activity. Involved in several processes, including cellular response to hydroxyurea; proteolysis; and regulation of DNA stability. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DDI2 Products (1)

mRNA Protein Name
NM_032341.5 NP_115717.3 protein DDI1 homolog 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables aspartic-type endopeptidase activity IDA
IDA: Inferred from direct assay
27528193 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
27461074 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
27528193 GOA
enables ubiquitin binding IDA
IDA: Inferred from direct assay
27461074 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to hydroxyurea IMP
IMP: Inferred from mutant phenotype
29290612 GOA
involved in proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
29290612 GOA
involved in protein processing IDA
IDA: Inferred from direct assay
27528193 GOA
involved in protein processing IMP
IMP: Inferred from mutant phenotype
27676298 GOA
involved in regulation of DNA stability IMP
IMP: Inferred from mutant phenotype
29290612 GOA
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
29290612 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDI2 Protein Structure

ubiquitin

ubiquitin: Ubiquitin family (13 - 77)

Asp_protease

Asp_protease: Aspartyl protease (212 - 335)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
Protein Preferred Names Protein Names

protein DDI1 homolog 2

  • DDI1, DNA-damage inducible 1, homolog 2

Related Diseases

Diseases Alias
Ngly1-Deficiency

  • Deficiency Of N-Glycanase 1

  • Ngly1-Cddg

  • Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome

  • Ngly1 Deficiency

  • Congenital Disorder Of Deglycosylation

  • Congenital Disorder Of Glycosylation Type Iv

  • Congenital Disorder Of Deglycosylation

  • Cddg

  • Congenital Disorder Of Glycosylation Type Iv

  • Cdg1v
Ruijs-Aalfs Syndrome

  • Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

  • RJALS
Combat Disorder

  • Combat Disorders

  • Combat Neurosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03612 DDI2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DDI2 MGD MGI:1917244
Rattus norvegicus DDI2 RGD RGD:1311815
Canis familiaris DDI2 VGNC VGNC:52126
Others DDI2 NCBI