country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

MICALL1 - MICAL like 1 Gene

Also Known as MIRAB13; MICAL-L1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 85377

About MICALL1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,906,297-37,942,822 (from NCBI)

This gene has 12 transcripts (splice variants), 215 orthologues and 7 paralogues. Ubiquitous expression in placenta (RPKM 11.0), esophagus (RPKM 10.9) and 25 other tissues.

Summary

Enables identical protein binding activity; phosphatidic acid binding activity; and small GTPase binding activity. Involved in several processes, including plasma membrane tubulation; protein localization to endosome; and slow endocytic recycling. Located in late endosome and recycling endosome membrane. Is extrinsic component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

MICALL1 Products (4)

mRNA	Protein	Name
NM_001410818.1	NP_001397747.1	MICAL-like protein 1 isoform 1
NM_001410819.1	NP_001397748.1	MICAL-like protein 1 isoform 2
NM_001410820.1	NP_001397749.1	MICAL-like protein 1 isoform 4
NM_033386.4	NP_203744.1	MICAL-like protein 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	23596323	GOA
enables phosphatidic acid binding	IDA IDA: Inferred from direct assay	23596323	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19864458	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	19864458	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	19864458	GOA
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	20801876	GOA
involved in plasma membrane tubulation	IDA IDA: Inferred from direct assay	23596323	GOA
involved in protein localization to endosome	IMP IMP: Inferred from mutant phenotype	23596323	GOA
involved in protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	19864458	GOA
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	21795389	GOA
involved in slow endocytic recycling	IMP IMP: Inferred from mutant phenotype	19864458	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic side of endosome membrane	IDA IDA: Inferred from direct assay	19864458	GOA
NOT located in early endosome	IDA IDA: Inferred from direct assay	21795389	GOA
located in late endosome	IDA IDA: Inferred from direct assay	21795389	GOA
NOT located in recycling endosome membrane	IDA IDA: Inferred from direct assay	21795389	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	19864458	GOA
NOT located in trans-Golgi network	IDA IDA: Inferred from direct assay	21795389	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MICALL1 Protein Structure

LIM

DUF3585

0
200
400
600
800
863 a.a.

Protein Preferred Names	Protein Names
MICAL-like protein 1	molecule interacting with Rab13

MICALL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MICALL1	Q8N3F8	EHD4	Homo sapiens	Q9H223	Pull Down	19864458
Intra	MICALL1	Q8N3F8	EHD4	Homo sapiens	Q9H223	Anti Tag CoIP	33961781
Intra	MICALL1	Q8N3F8	EHD3	Homo sapiens	Q9NZN3	Y2H	19864458
Intra	MICALL1	Q8N3F8	EHD3	Homo sapiens	Q9NZN3	Anti Tag CoIP	33961781
Intra	MICALL1	Q8N3F8	EHD3	Homo sapiens	Q9NZN3	Y2H	27189942
Intra	MICALL1	Q8N3F8	EHD3	Homo sapiens	Q9NZN3	Pull Down	19864458
Intra	MICALL1	Q8N3F8	EHD1	Homo sapiens	Q9H4M9	Pull Down	19864458
Intra	MICALL1	Q8N3F8	EHD1	Homo sapiens	Q9H4M9	Anti Tag CoIP	33961781
Cross	MICALL1	Q8N3F8	DPYSL2	Bos taurus	O02675	Pull Down	20801876

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bardet-Biedl Syndrome 5	BBS5 Bardet-Biedl Syndrome, Type 5
Microvillus Inclusion Disease	Congenital Microvillous Atrophy Intractable Diarrhea Of Infancy Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities Davidson Disease Microvillous Inclusion Disease Congenital Microvillus Atrophy Mvid Diarrhea 2 With Microvillus Atrophy Mvd Congenital Familial Protracted Diarrhea Davidson'S Disease Familial Enteropathy, Microvillus Microvillus Atrophy, Congenital Congenital Enteropathy Familial Protracted Enteropathy Microvillous Atrophy Microvillus Atrophy With Diarrhea 2 Idi
Robinow Syndrome, Autosomal Dominant 1	Autosomal Dominant Robinow Syndrome 1 DRS1 Robinow Dwarfism Fetal Face Syndrome Acral Dysostosis With Facial And Genital Abnormalities Robinow, Autosomal Dominant Syndrome, Type 1
Retinitis Pigmentosa 39	RP39 Retinitis Pigmentosa, Type 39

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08428	MICALL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MICALL1	VGNC	VGNC:54528
Bos taurus	MICALL1	VGNC	VGNC:52803
Macaca mulatta	MICALL1	VGNC	VGNC:107801
Felis catus	MICALL1	VGNC	VGNC:97508
Mus musculus	MICALL1	MGD	MGI:105870
Rattus norvegicus	MICALL1	RGD	RGD:1305415
Others	MICALL1	NCBI