CGP11952 

CGP11952 is a triazolyl-Benzaphenon resembling the benzodiazepines in its pharmacological action. CGP11952 is an experimental benzodiazepine derivative.

Benzodiazepine^[2]

CGP11952 (CGP 11952) is a triazolyl-Benzaphenon resembling the benzodiazepines in its pharmacological action^[1]. The effects of CGP11952 (CGP 11.952), a triazolyl Benzophenone, on cognitive functioning are assessed by means of a computerized neuropsychological battery. In the first study CGP11952 turns out to have a positive effect on information processing speed, perceptual sensitivity and preciseness of responses. Negative effects are found on reaction time. In the second study this latter effect is less clear. A striking result is the less negative effect on memory consolidation under influence of CGP11952 in comparison with other benzodiazepines^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

446.33

C₂₁H₂₁Cl₂N₅O₂

64078-09-7

O=C(C1=NN(C2=CC=C(Cl)C=C2C(C3=CC=CC=C3Cl)=O)C(CN(C)C)=N1)NCC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Van Wieringen A, et al. Electroencephalographic findings in antiepileptic drug trials: a review and report of 6 studies. Epilepsy Res. 1987 Jan;1(1):3-15.  [Content Brief]

  [2]. Alpherts WC, et al. CGP 11.952: an experimental benzodiazepine derivative. Effects on cognitive functioning in patients with epilepsy. Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(6):673-82.  [Content Brief]