1. GPCR/G Protein
  2. GNRH Receptor
  3. Leuprolide Acetate

Leuprolide Acetate (Synonyms: Leuprorelin acetate)

Cat. No.: HY-13665 Purity: 99.88%
Handling Instructions

Leuprolide acetate (Leuprorelin acetate) is a potent gonadotropin-releasing hormone receptor agonist used for the treatment of prostate cancer, endometriosis, uterine fibroids.

For research use only. We do not sell to patients.

Leuprolide Acetate Chemical Structure

Leuprolide Acetate Chemical Structure

CAS No. : 74381-53-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 151 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg USD 216 In-stock
Estimated Time of Arrival: December 31
100 mg USD 336 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Leuprolide acetate (Leuprorelin acetate) is a potent gonadotropin-releasing hormone receptor agonist used for the treatment of prostate cancer, endometriosis, uterine fibroids.

Clinical Trial
Molecular Weight

1269.45

Formula

C₆₁H₈₈N₁₆O₁₄

CAS No.

74381-53-6

Sequence

Pyr-His-Trp-Ser-Tyr-{d-Leu}-Leu-Arg-Pro-NHEt

Sequence Shortening

Pyr-HWSY-{d-Leu}-LRP-NHEt

SMILES

CC(O)=O.O=C(N[[email protected]@H](CO)C(N[[email protected]](C(N[[email protected]](CC(C)C)C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CCCNC(N)=N)C(N(CCC1)[[email protected]@H]1C(NCC)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)[[email protected]@H](NC([[email protected]@H](NC([[email protected]@H](N3)CCC3=O)=O)CC4=CNC=N4)=O)CC5=CNC6=C5C=CC=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 66.66 mg/mL (52.51 mM)

DMSO : 25 mg/mL (19.69 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7877 mL 3.9387 mL 7.8774 mL
5 mM 0.1575 mL 0.7877 mL 1.5755 mL
10 mM 0.0788 mL 0.3939 mL 0.7877 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (1.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (1.71 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (1.71 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.88%

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  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

LeuprolideLeuprorelinGNRH ReceptorGonadotropin releasing hormone receptorGNRHRInhibitorinhibitorinhibit

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Product name:
Leuprolide Acetate
Cat. No.:
HY-13665
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