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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
Nutlin 3
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "Nutlin 3" in MCE Product Catalog:
69
69 Publications Verification
Synonyms: Rebemadlin
Target:
Research Areas:
Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas .
43
43 Cited Publications
Cat. No.: HY-50696
CAS No.: 548472-68-0
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Research Areas:
Nutlin-3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM.
2
2 Cited Publications
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Research Areas:
Nutlin-3b, the inactive form of Nutlin-3 (HY-50696), is a p53/MDM2 inhibitor with an IC50 of 13.6 μM. Nutlin-3b is 150 times less potent in binding to MDM2 than Nutlin-3a (HY-10029). Nutlin-3b is promising for research of cancers .
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Nutlin carboxylic acid is the Nutlin 3-based MDM2 ligand. Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTAC .
Cat. No.: HY-50696R
CAS No.: 548472-68-0
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Nutlin-3 (Standard) is the analytical standard of Nutlin-3. This product is intended for research and analytical applications. Nutlin-3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM.
Cat. No.: HY-128836
CAS No.: 2306390-08-7
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(4R,5S)-Nutlin carboxylic acid is a MDM2 ligand and also a nutlin-3 derivative. (4R,5S)-Nutlin carboxylic acid can be linked to target protein ligands via a linker to form a PROTAC that can be used for targeting PARP1 .
Cat. No.: HY-10029A
CAS No.: 890090-75-2
Synonyms: (Rac)-Rebemadlin
Target:
Research Areas:
(Rac)-Nutlin-3 (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). (Rac)-Nutlin-3 inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. (Rac)-Nutlin-3 has the potential for the study of TP53 wild-type ovarian carcinomas .
Cat. No.: HY-10029R
CAS No.: 675576-98-4
Synonyms: Rebemadlin (Standard)
Research Areas:
Nutlin-3a (Standard) is the analytical standard of Nutlin-3a (HY-10029). This product is intended for research and analytical applications. Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas .
Cat. No.: HY-128837A
CAS No.: 2760669-71-2
Research Areas:
(rel)-Nutlin carboxylic acid is the Nutlin 3-based MDM2 ligand. (rel)-Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTAC .
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Research Areas:
Caylin-2 is a Bcl-XL binder and analog of Nutlin-3 (HY-50696). Caylin-2 interacts with the hydrophobic groove of Bcl-XL, with binding diminished by steric collision from its trifluoromethyl groups. Caylin-2 can be used for cancer research .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
