1207480-88-3
1207480-88-3
Chemical Structure
Caylin-1
- CAS No.: 1207480-88-3
- Formula:C30H28Cl4N4O4
- Molecular Weight:650.38
IUPAC Name: 4-((4R,5S)-4,5-bis(3,4-dichlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
InChIKey: SOQGENPVVRSGAY-IZLXSDGUSA-N
SMILES: O=C1NCCN(C(N2[C@@H](C3=CC=C(Cl)C(Cl)=C3)[C@@H](C4=CC=C(Cl)C(Cl)=C4)N=C2C5=CC=C(OC)C=C5OC(C)C)=O)C1
Biological Activity: Caylin-1 is an inhibitor of MDM2 and an analog of Nutlin-3. Caylin-1 can bind to Bcl-XL and is used in multi-target anticancer research[1][2].
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Caylin-1 | Caylin-1 is an inhibitor of MDM2 and an analog of Nutlin-3. Caylin-1 can bind to Bcl-XL and is used in multi-target anticancer research. | |||||||||||||||||||||
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References
- [1]. Shin J S, et al. Structural insights into the dual-targeting mechanism of Nutlin-3[J]. Biochemical and Biophysical Research Communications, 2012, 420(1): 48-53. [Content Brief]
- [2]. Li J, et al. A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53–MDM2 interaction[J]. Journal of biomolecular screening, 2011, 16(4): 450-456. [Content Brief]
Keywords
