2306390-08-7
Chemical Structure
(4R,5S)-Nutlin carboxylic acid
- CAS No.: 2306390-08-7
- Formula:C32H32Cl2N4O6
- Molecular Weight:639.53
IUPAC Name: 2-(4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetic acid
InChIKey: CYFZSMNCDNFMOG-IHLOFXLRSA-N
SMILES: O=C1N(CC(O)=O)CCN(C(N2[C@@H](C3=CC=C(Cl)C=C3)[C@@H](C4=CC=C(Cl)C=C4)N=C2C5=CC=C(OC)C=C5OC(C)C)=O)C1
Biological Activity: (4R,5S)-Nutlin carboxylic acid is a MDM2 ligand and also a nutlin-3 derivative. (4R,5S)-Nutlin carboxylic acid can be linked to target protein ligands via a linker to form a PROTAC that can be used for targeting PARP1[1].
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(4R,5S)-Nutlin carboxylic acid | (4R,5S)-Nutlin carboxylic acid is a MDM2 ligand and also a nutlin-3 derivative. (4R,5S)-Nutlin carboxylic acid can be linked to target protein ligands via a linker to form a PROTAC that can be used for targeting PARP1. | |||||||||||||||||||||
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Keywords
