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Cat. No.: HY-128837A

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(rel)-Nutlin carboxylic acid

(rel)-Nutlin carboxylic acid is the Nutlin 3-based MDM2 ligand. (rel)-Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTAC.

For research use only. We do not sell to patients.

CAS No.: 2760669-71-2
Formula: C₃₂H₃₂Cl₂N₄O₆
Molecular Weight:639.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

(rel)-Nutlin carboxylic acid Chemical Structure

CAS No.: 2760669-71-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(rel)-Nutlin carboxylic acid is the Nutlin 3-based MDM2 ligand. (rel)-Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTAC^[1].

IC₅₀ & Target^[1]

MDM2

All Ligands for E3 Ligase Isoforms :

Chemical Information

CAS No. 2760669-71-2
Molecular Weight 639.53
Formula C₃₂H₃₂Cl₂N₄O₆
SMILES

O=C(N1CC(N(CC1)CC(O)=O)=O)N2[C@H](C3=CC=C(C=C3)Cl)[C@H](C4=CC=C(C=C4)Cl)N=C2C5=C(C=C(C=C5)OC)OC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li G, et al. A PARP1 PROTAC as a novel strategy against PARP inhibitor resistance via promotion of ferroptosis in p53-positive breast cancer. Biochem Pharmacol. 2022 Dec;206:115329. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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(rel)-Nutlin carboxylic acid

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(rel)-Nutlin carboxylic acid Related Classifications

HY-128837A Related Classifications