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PSI-697 (Synonyms: P-Selectin Inhibitor)

Cat. No.: HY-15526 Purity: 99.61%
Handling Instructions

PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM.

For research use only. We do not sell to patients.

PSI-697 Chemical Structure

PSI-697 Chemical Structure

CAS No. : 851546-61-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 340 In-stock
Estimated Time of Arrival: December 31
1 mg USD 168 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM[1].

IC50 & Target

IC50: 125 μM (P-selectin)[1]

In Vitro

PSI-697 inhibits the binding of a soluble human P-selectin to PSGL-1, in a reproducible concentration-dependent manner inhibiting 50% of binding at a concentration of 125 μM in vitro[1].

In Vivo

PSI-697 (0-50 mg/kg; p.o.) significantly reduces the number of rolling leukocytes by 39% versus vehicle control[1].
PSI-697 (100 mg/kg; p.o.) reduces thrombus weight by 18% relative to vehicle, without prolonging bleeding time in a rat venous thrombosis model[1].
PSI-697 (30 mg/kg; p.o.; daily; 6 days) promotes thrombus resolution and decreases inflammation in a baboon model of venous thrombosis[2].
PSI-697 ((30 mg/kg; i.g.; daily) decreases vein wall injury in a rat stenosis model of venous thrombosis[2].

Animal Model: 4–5 weeks male Sprague-Dawley rat (50–100 g)[1]
Dosage: 0 mg/kg, 30 mg/kg, 50 mg/kg
Administration: Oral administration
Result: At an oral dose of 50 mg/kg reduced the number of rolling leukocytes by 39% versus vehicle control.
Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 45.8 mg/mL (124.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7186 mL 13.5932 mL 27.1865 mL
5 mM 0.5437 mL 2.7186 mL 5.4373 mL
10 mM 0.2719 mL 1.3593 mL 2.7186 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

367.83

Formula

C₂₁H₁₈ClNO₃

CAS No.

851546-61-7

SMILES

O=C(C1=C(O)C(CC2=CC=C(Cl)C=C2)=NC3=C(CCCC4)C4=CC=C13)O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
PSI-697
Cat. No.:
HY-15526
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PSI-697

Cat. No.: HY-15526