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PSI-697 (Synonyms: P-Selectin Inhibitor)

Cat. No.: HY-15526 Purity: 99.70%
Handling Instructions

PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM.

For research use only. We do not sell to patients.

PSI-697 Chemical Structure

PSI-697 Chemical Structure

CAS No. : 851546-61-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 340 In-stock
Estimated Time of Arrival: December 31
1 mg USD 168 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    PSI-697 purchased from MCE. Usage Cited in: Chem Eng J. 382 (2020) 122848.

    Localization of NPs in H22 bearing tumor tissues. Mice bearing H22 tumors are intravenously injected with [email protected] NPs and PSI-697 pre-treated (20 μg mL-1, 1 h) [email protected] NPs. 24 h later, the tumors were removed and sectioned under frozen conditions followed by staining with an antibody against CD44 (green).
    • Biological Activity

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    Description

    PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM[1].

    IC50 & Target

    IC50: 125 μM (P-selectin)[1]

    In Vitro

    PSI-697 inhibits the binding of a soluble human P-selectin to PSGL-1, in a reproducible concentration-dependent manner inhibiting 50% of binding at a concentration of 125 μM in vitro[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    PSI-697 (0-50 mg/kg; p.o.) significantly reduces the number of rolling leukocytes by 39% versus vehicle control[1].
    PSI-697 (100 mg/kg; p.o.) reduces thrombus weight by 18% relative to vehicle, without prolonging bleeding time in a rat venous thrombosis model[1].
    PSI-697 (30 mg/kg; p.o.; daily; 6 days) promotes thrombus resolution and decreases inflammation in a baboon model of venous thrombosis[2].
    PSI-697 ((30 mg/kg; i.g.; daily) decreases vein wall injury in a rat stenosis model of venous thrombosis[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 4-5 weeks male Sprague-Dawley rat (50-100 g)[1]
    Dosage: 0 mg/kg, 30 mg/kg, 50 mg/kg
    Administration: Oral administration
    Result: At an oral dose of 50 mg/kg reduced the number of rolling leukocytes by 39% versus vehicle control.
    Clinical Trial
    Molecular Weight

    367.83

    Formula

    C₂₁H₁₈ClNO₃

    CAS No.

    851546-61-7

    SMILES

    O=C(C1=C(O)C(CC2=CC=C(Cl)C=C2)=NC3=C(CCCC4)C4=CC=C13)O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 45.8 mg/mL (124.51 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7186 mL 13.5932 mL 27.1865 mL
    5 mM 0.5437 mL 2.7186 mL 5.4373 mL
    10 mM 0.2719 mL 1.3593 mL 2.7186 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 99.70%

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    Keywords:

    PSI-697P-Selectin InhibitorPSI697PSI 697OthersInhibitorinhibitorinhibit

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    Product Name:
    PSI-697
    Cat. No.:
    HY-15526
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