PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4114)
Related Products (4114)
-
PROTAC Linkers Isoform Comparison
-
H2N-PEG4-Hydrazide
0 ImagesCat. No.: HY-133339CAS No.: 1425973-15-4
-
14-((tert-Butoxycarbonyl)amino)tetradecanoic acid
0 ImagesCat. No.: HY-W882949CAS No.: 2307778-46-5
-
4,4'-(Hexane-1,6-diylbis(oxy))dibenzonitrile
0 ImagesCat. No.: HY-W488303CAS No.: 94291-61-9
-
Bn-PEG8-OBn
0 ImagesCat. No.: HY-W109023CAS No.: 105891-54-1
-
tert-Butyl 2-(piperidin-4-yl)acetate hydrochloride
0 ImagesCat. No.: HY-W242595CAS No.: 2174007-91-9
-
OH-PEG3-Cl
0 ImagesCat. No.: HY-W250348CAS No.: 5197-66-0
-
1-Bromo-4-(4-bromobutyl)benzene
0 ImagesCat. No.: HY-23690CAS No.: 88999-91-1
-
3-Cyanocyclobutane-1-carboxylic acid
0 ImagesCat. No.: HY-W036156CAS No.: 1823933-75-0
-
Ethyl hex-5-ynoate
0 ImagesCat. No.: HY-W453529CAS No.: 108545-38-6
-
tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W094102CAS No.: 864754-13-2
-
HO-PEG8-CH2COOH
0 ImagesCat. No.: HY-133301CAS No.: 780006-30-6
-
2-Propargyl-(trans)-4-cyclohexanediamine
0 ImagesCat. No.: HY-W064523CAS No.: 1266328-42-0
-
3-Hydroxy-2,2,4,4-tetramethylcyclobutan-1-one oxime
0 ImagesCat. No.: HY-W998341CAS No.: 13900-80-6
