2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Pyruvate Kinase
  5. PKM2 Isoform
  6. PKM2 Activator

PKM2 Activator

PKM2 Activators (2):

Cat. No. Product Name Effect Purity
  • HY-180795
    PKM2 activator 11
    		Activator
    PKM2 activator 11 (Compound 23) is a PKM2 activator with an AC50 value of 92.12 nM. PKM2 activator 11 promotes PKM2 tetramerization and inhibits its nuclear translocation. PKM2 activator 11 suppresses glycolysis and the PKM2/STAT3 signaling pathway. PKM2 activator 11 induces Apoptosis. PKM2 activator 11 exhibits anti-CRC activity in vitro with potency and selectivity.
  • HY-111936
    ML 083
    		Activator
    ML083 is a member of a series of highly specific allosteric activators for the tumor-specific isoform of human pyruvate kinase (M2 isoform). ML083 affects the cooperativity of phosphoenolpyruvate (PEP) binding. ML083 can be used in the research of tumors.