2. Signaling Pathways
  3. Apoptosis
    Autophagy
    Cell Cycle/DNA Damage
    Immunology/Inflammation
  4. FKBP
  5. FKBP51 Isoform
  6. FKBP51 Degrader

FKBP51 Degrader

FKBP51 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-181289
    SelDeg51
    		Degrader
    SelDeg51 is a selective FKBP51 PROTAC degrader with a Kd value of 18 nM and a Dmax of 90%. SelDeg51 induces proteasomal degradation of FKBP51 via the FKBP51:SelDeg51:VCB ternary complex and reactivates the glucocorticoid receptor signaling pathway. SelDeg51 can be used for research on stress-related mental disorders, chronic pain, and obesity.