2. PROTAC Cell Cycle/DNA Damage Autophagy Apoptosis Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  3. PROTACs FKBP Glucocorticoid Receptor
  4. SelDeg51

SelDeg51 is a selective FKBP51 PROTAC degrader with a Kd value of 18 nM and a Dmax of 90%. SelDeg51 induces proteasomal degradation of FKBP51 via the FKBP51:SelDeg51:VCB ternary complex and reactivates the glucocorticoid receptor signaling pathway. SelDeg51 can be used for research on stress-related mental disorders, chronic pain, and obesity.
(Pink: Target protein ligand; Blue: VHL ligand (HY-125905); Black: linker).

For research use only. We do not sell to patients.

SelDeg51

SelDeg51 Chemical Structure

CAS No. : 3036372-80-9

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SelDeg51 Related Antibodies

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Description

SelDeg51 is a selective FKBP51 PROTAC degrader with a Kd value of 18 nM and a Dmax of 90%. SelDeg51 induces proteasomal degradation of FKBP51 via the FKBP51:SelDeg51:VCB ternary complex and reactivates the glucocorticoid receptor signaling pathway. SelDeg51 can be used for research on stress-related mental disorders, chronic pain, and obesity[1]. (Pink: Target protein ligand; Blue: VHL ligand (HY-125905); Black: linker).

IC50 & Target[1]

VHL

 

FKBP51

18 nM (Kd)

In Vitro

SelDeg51 (0.6-10 μM; 0-48 h) degrades FKBP51 in a time-dependent and reversible manner in HEK293T cells, with high selectivity for FKBP12[1].
SelDeg51 (250 nM) enhances Dexamethasone (HY-14648)-induced expression of endogenous glucocorticoid receptor target genes GILZ and FKBP5 in A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SelDeg51 Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 1 μM
Incubation Time: 0, 2, 4, 6, 8, 24 and 48 h
Result: Reduced FKBP51 protein levels.
Did not affact FKBP12 protein levels.
Molecular Weight

1343.60

Formula

C72H91FN8O14S
CAS No.
SMILES

O=C(N1CCCC[C@H]1C(O[C@H](CCC2=CC(OC)=C(OC)C=C2)C3=CC=C(OCC4=CN(CCCOC5=C(CNC([C@@H]6C[C@@H](O)CN6C([C@H](C(C)(C)C)NC(C7(CC7)F)=O)=O)=O)C=CC(C8=C(C)N=CS8)=C5)N=N4)C=C3)=O)[C@H](C9=CC(OC)=C(OC)C(OC)=C9)C%10CCCCC%10
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SelDeg51 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SelDeg513036372-80-9SelDeg 51SelDeg-51PROTACsFKBPGlucocorticoid ReceptorFK506-binding proteinHEK293T cellsVHLFKBP12FKBP51A549 cellsInhibitorinhibitorinhibit

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