2. Signaling Pathways
  3. Neuronal Signaling
  4. Prion Protein
  5. Prion Protein Ligand

Prion Protein Ligand

Prion Protein Ligand (1):

Cat. No. Product Name Effect Purity
  • HY-183849
    H9-KGDEVD-MMAE
    		Ligand
    H9-KGDEVD-MMAE is an antibody-drug conjugate that specifically binds to PRND to enable precise drug delivery to tumor vasculature and cancer cells. H9-KGDEVD-MMAE contains a linker cleavable by cathepsin B and caspase-3/7, allowing the release of MMAE in lysosomes. H9-KGDEVD-MMAE induces apoptosis, produces a bystander effect, and disrupts tumor vasculature. H9-KGDEVD-MMAE achieves deep tumor penetration and exhibits durable anti-tumor efficacy without systemic toxicity in preclinical models of highly vascularized malignant tumors. H9-KGDEVD-MMAE can be applied to research related to glioblastoma, sarcoma, and renal cell carcinoma.