1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor

YL0919 

Cat. No.: HY-100769 Purity: 99.84%
Handling Instructions

YL0919, a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor,the IC50 values of YL-0919 inhibiting the uptake of 5-HT into rat cerebral cortical synaptosomes and human recombinant cells were 1.78±0.34 nM and 1.93±0.18 nM respectively.

For research use only. We do not sell to patients.

YL0919 Chemical Structure

YL0919 Chemical Structure

CAS No. : 1339058-04-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 199 In-stock
Estimated Time of Arrival: December 31
2 mg USD 108 In-stock
Estimated Time of Arrival: December 31
5 mg USD 252 In-stock
Estimated Time of Arrival: December 31
10 mg USD 372 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1188 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

YL0919, a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor,the IC50 values of YL-0919 inhibiting the uptake of 5-HT into rat cerebral cortical synaptosomes and human recombinant cells were 1.78±0.34 nM and 1.93±0.18 nM respectively. target: 5-HT1A receptor IC50:1.78±0.34 nM(rat cerebral cortical synaptosomes) IC50:1.93±0.18 nM(human recombinant cells)[1]" In vivo: WAY-100635 completely antagonized the antidepressant-like activity of YL-0919 in both behavioral models, suggesting that activation of the 5-HT1A receptor is critical in the antidepressant-like effect of YL-0919. The administered dose of WAY-100635 ranged from 0.1–0.3 mg/kg, which reportedly has no effect on locomotor activity and only blocks the activation of 5-HT1A receptor.[2]

Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (89.60 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9865 mL 14.9325 mL 29.8650 mL
5 mM 0.5973 mL 2.9865 mL 5.9730 mL
10 mM 0.2987 mL 1.4933 mL 2.9865 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

334.84

Formula

C₁₈H₂₃ClN₂O₂

CAS No.

1339058-04-6

SMILES

O=C1C=CC=CN1CC2(O)CCN(CC3=CC=CC=C3)CC2.[H]Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
YL0919
Cat. No.:
HY-100769
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YL0919

Cat. No.: HY-100769