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acbut

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-109539
    Gemtuzumab ozogamicin
    1 Publications Verification

    Antibody-Drug Conjugates (ADCs) Apoptosis Cancer
    Gemtuzumab ozogamicin is an antibody-drug conjugate (ADC) consisting of a humanized immunoglobulin (IgG4) antibody directed against CD33 that is conjugated to the cytotoxic agent Calicheamicin (HY-19609). The antibody portion is Gemtuzumab (HY-P99971), and the drug-linker conjugate for ADC is N-Ac-γ-Calicheamicin-AcBut-NHS ester (HY-103688). Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia (AML) .
    Gemtuzumab ozogamicin
  • HY-103688

    ADC Payload Cancer
    AcBut-N-Ac-γ-Calicheamicin is an ADC cytotoxic payload that induces cell cycle arrest and apoptosis by causing DNA double-strand breaks. AcBut-N-Ac-γ-Calicheamicin is primarily used in the synthesis of antibody-drug conjugates (ADC) and holds promise for research in the field of cancer, including acute lymphoblastic leukemia (ALL) and other hematological malignancies .
    N-Ac-γ-Calicheamicin-AcBut-NHS ester
  • HY-132261

    4-(4-Acetyl-phenoxy)-butyric acid

    ADC Linker Cancer
    AcBut (4-(4-Acetyl-phenoxy)-butyric acid) is a cleavable linker for Ozogamicin synthesis, and Ozogamicin is a drug-linker conjugate for ADC .
    AcBut

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