IFNLR1 Antibody
(Synonyms: CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2)IFNLR1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IFNLR1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Spplied in pH 7.4 PBS, 0.05% NaN3, 40% Glycerol.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:2000 |
Product Details
IFNLR1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IFNLR1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman
Synthetic peptide of human IFNLR1.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in pH 7.4 PBS, 0.05% NaN3, 40% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IFNLR1 is a The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium
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Subcellular Localization
Membrane
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Expression
Tissue_Specificity: Widely expressed. -
Isoforms & Post-Translational Modification
IFNLR1 has 4 isoforms, Q8IU57-1: amino acid length is 520, molecular weight is 57653 Da (predicted); Q8IU57-2: amino acid length is 491, molecular weight is 54415 Da (predicted); Q8IU57-3: amino acid length is 211, molecular weight is 23689 Da (predicted); Q8IU57-4: amino acid length is 244, molecular weight is 27536 Da (predicted).
Ubiquitinated by FBXO45-containing E3 ligase leading to proteasomal degradation -
Subunit
Heterodimer with IL10RB
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SwissProt ID
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Synonyms
CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2
Documentation
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