PSMC6 Antibody
(Synonyms: SUG2, PSMC6, 26S proteasome regulatory subunit 10B, 26S proteasome AAA-ATPase subunit RPT4, Proteasome 26S subunit ATPase 6, Proteasome subunit p42)PSMC6 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PSMC6.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol and 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:1000-1500 |
Product Details
PSMC6 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PSMC6.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 44 kDa
Recombinant protein of Human PSMC6 (aa 1-200).
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol and 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PSMC6 is a component of the 26S proteasome complex and participates in the degradation of ATP-dependent ubiquitinated proteins. This complex plays a crucial role in maintaining protein homeostasis by clearing misfolded or damaged proteins (which can impair cellular function) and removing unwanted proteins. Therefore, the proteasome is involved in various cellular processes, including cell cycle progression, apoptosis, and DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with various cellular activities) proteins, which can unwrap ubiquitinated target proteins and transport them to the proteolytic chamber for degradation into peptides.
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Subcellular Localization
Cytoplasm, Nucleus
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Isoforms & Post-Translational Modification
PSMC6: 389 amino acids, molecular weight 44,173 Da.
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Subunit
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC6 and few additional components. Interacts with PAAF1.
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SwissProt ID
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Synonyms
SUG2, PSMC6, 26S proteasome regulatory subunit 10B, 26S proteasome AAA-ATPase subunit RPT4, Proteasome 26S subunit ATPase 6, Proteasome subunit p42
Documentation
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