PROTACs Ligand
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MPD2
0 ImagesArt. -Nr.: HY-162464MPD2 is a Cereblon (CRBN) ligand and SARS-CoV-2 MPro degrader with an IC50 <1000 nM against SARS-CoV-2 MPro. MPD2 engages CRBN to mediate ubiquitination and proteasomal degradation of SARS-CoV-2 MPro, reducing SARS-CoV-2 MPro protein levels in infected cells. MPD2 inhibits viral replication of various SARS-CoV-2 strains and acts against nirmatrelvir-resistant SARS-CoV-2 viruses. MPD2 can be used for the research of covid-19 and for fighting against drug-resistant viral variants..
