FTISADTSK-13C 6,15N2(TFA)
Based on 1 Customer Validation
FTISADTSK-13C6,15N2 TFA is 13C- and 15N-labeled FTISADTSK (HY-P3146). FTISADTSK is an endogenous stable signature peptide from Trastuzumab monitored by selected reaction monitoring (SRM).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 96.04%
- Formel: C3813C6H69F3N815N2O18
- Molecular Weight:1091.01
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Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 1431957-73-1
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Appearance Solid
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Molecular Weight 1091.01
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Formel C3813C6H69F3N815N2O18
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Color White to off-white
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SMILES
O=C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C([15NH][13C@@H]([13CH2][13CH2][13CH2][13CH2][15NH2])[13C](O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)NC([C@H]([C@H](O)C)NC([C@@H](N)CC1=CC=CC=C1)=O)=O.O=C(C(F)(F)F)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (91.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-220. [Content Brief]
[2]. Bults P, et al. LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma. Anal Chem. 2016;88(3):1871-1877. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.9166 mL | 4.5829 mL | 9.1658 mL | 22.9145 mL |
| 5 mM | 0.1833 mL | 0.9166 mL | 1.8332 mL | 4.5829 mL | |
| 10 mM | 0.0917 mL | 0.4583 mL | 0.9166 mL | 2.2915 mL | |
| 15 mM | 0.0611 mL | 0.3055 mL | 0.6111 mL | 1.5276 mL | |
| 20 mM | 0.0458 mL | 0.2291 mL | 0.4583 mL | 1.1457 mL | |
| 25 mM | 0.0367 mL | 0.1833 mL | 0.3666 mL | 0.9166 mL | |
| 30 mM | 0.0306 mL | 0.1528 mL | 0.3055 mL | 0.7638 mL | |
| 40 mM | 0.0229 mL | 0.1146 mL | 0.2291 mL | 0.5729 mL | |
| 50 mM | 0.0183 mL | 0.0917 mL | 0.1833 mL | 0.4583 mL | |
| 60 mM | 0.0153 mL | 0.0764 mL | 0.1528 mL | 0.3819 mL | |
| 80 mM | 0.0115 mL | 0.0573 mL | 0.1146 mL | 0.2864 mL |
FTISADTSK-13C 6,15N2(TFA) Related Classifications
HY-P3146S Related Classifications
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