PDIA6 - protein disulfide isomerase family A member 6 Gene

Also Known as P5; ERP5; TXNDC7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10130

About PDIA6

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:10,783,391-10,837,712 (from NCBI)

This gene has 8 transcripts (splice variants), 223 orthologues, 13 paralogues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 159.7), placenta (RPKM 70.6) and 25 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

PDIA6 Products (5)

mRNA Protein Name
NM_001282704.2 NP_001269633.1 protein disulfide-isomerase A6 isoform a
NM_001282705.2 NP_001269634.1 protein disulfide-isomerase A6 isoform b
NM_001282706.2 NP_001269635.1 protein disulfide-isomerase A6 isoform c
NM_001282707.2 NP_001269636.1 protein disulfide-isomerase A6 isoform e precursor
NM_005742.4 NP_005733.1 protein disulfide-isomerase A6 isoform d precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
15466936 GOA
enables protein-disulfide reductase activity IDA
IDA: Inferred from direct assay
16677074 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
15308636 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
19995400 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDIA6 Protein Structure

Thioredoxin

Thioredoxin: Thioredoxin (27 - 126)

Thioredoxin

Thioredoxin: Thioredoxin (162 - 263)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
Protein Preferred Names Protein Names

protein disulfide-isomerase A6

  • ER protein 5

PDIA6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PDIA6 Q15084 PRDX4 Homo sapiens Q13162
Enzymatic Study
21057456
Intra
PDIA6 Q15084 HSPA5 Homo sapiens P11021
Crosslink
30021884
Intra
PDIA6 Q15084 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDIA6 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P71193 PDIA6 Protein, Human (HEK293, His) Q15084 (L20-L440) ≥ 95%, as determined by reducing SDS-PAGE.

PDIA6 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P80271 PDIA6 Antibody (YA237) WB, ICC/IF, IHC-P, IHC-F, IF-Tissue Human, Mouse, Rat

Orthologs Information

Species Symbol Source ID
Macaca mulatta PDIA6 VGNC VGNC:75895
Mus musculus PDIA6 MGD MGI:1919103
Bos taurus PDIA6 VGNC VGNC:32700
Canis familiaris PDIA6 VGNC VGNC:103696
Felis catus PDIA6 VGNC VGNC:64086
Rattus norvegicus PDIA6 RGD RGD:628688
Others PDIA6 NCBI