Lims1 - LIM and senescent cell antigen-like domains 1 Gene

Also Known as PINCH; Lims1l; PINCH1; 2310016J22Rik; 4921524A02Rik; C430041B13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110829

Summary

Predicted to enable protein kinase binding activity and zinc ion binding activity. Acts upstream of or within several processes, including cell-matrix adhesion; negative regulation of cell population proliferation; and positive regulation of integrin-mediated signaling pathway. Located in focal adhesion. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and liver and biliary system. Orthologous to human LIMS1 (LIM zinc finger domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Lims1 Products (6)

mRNA Protein Name
NM_001193303.1 NP_001180232.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform 3
NM_001346676.1 NP_001333605.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform 4
NM_001359115.1 NP_001346044.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform 5
NM_001359116.1 NP_001346045.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform 6
NM_026148.4 NP_080424.2 LIM and senescent cell antigen-like-containing domain protein 1 isoform 1
NM_201242.1 NP_957694.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
12432066 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
15976450 MGI
acts upstream of or within cell-cell junction organization IGI
IGI: Inferred from genetic interaction
19652092 MGI
acts upstream of or within cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
15976450 MGI
acts upstream of cholangiocyte proliferation IGI
IGI: Inferred from genetic interaction
24058607 MGI
acts upstream of or within chordate embryonic development IMP
IMP: Inferred from mutant phenotype
15798193 MGI
acts upstream of or within establishment or maintenance of cell polarity IMP
IMP: Inferred from mutant phenotype
15976450 MGI
acts upstream of hepatocyte apoptotic process IGI
IGI: Inferred from genetic interaction
24058607 MGI
acts upstream of integrin-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
19652092 MGI
acts upstream of or within negative regulation of cholangiocyte proliferation IGI
IGI: Inferred from genetic interaction
24058607 MGI
acts upstream of or within negative regulation of hepatocyte apoptotic process IGI
IGI: Inferred from genetic interaction
24058607 MGI
acts upstream of or within negative regulation of hepatocyte proliferation IGI
IGI: Inferred from genetic interaction
24058607 MGI
acts upstream of or within negative regulation of neural precursor cell proliferation IGI
IGI: Inferred from genetic interaction
24719101 MGI
acts upstream of neural precursor cell proliferation IGI
IGI: Inferred from genetic interaction
24719101 MGI
acts upstream of or within positive regulation of integrin-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
19652092 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in focal adhesion IDA
IDA: Inferred from direct assay
12432066 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

LIM and senescent cell antigen-like-containing domain protein 1

  • particularly interesting new Cys-His protein 1

Recombinant Lims1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P72064 LIMS1 Protein, Mouse (sf9, His) Q99JW4 (A2-K325) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS07668 LIMS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18827 Lims1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25318 Lims1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lims1 NCBI NCBI:3987