CTSV - cathepsin V Gene

Also Known as CTSU; CATL2; CTSL2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1515

About CTSV

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:97,029,677-97,039,643 (from NCBI)

This gene has 16 transcripts (splice variants), 711 orthologues and 12 paralogues. Biased expression in testis (RPKM 18.5), skin (RPKM 8.5) and 3 other tissues.

Summary

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]

CTSV Products (2)

mRNA Protein Name
NM_001201575.2 NP_001188504.1 cathepsin L2 preproprotein
NM_001333.4 NP_001324.2 cathepsin L2 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
12809493 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTSV Protein Structure

Inhibitor_I29

Inhibitor_I29: Cathepsin propeptide inhibitor domain (I29) (29 - 88)

Peptidase_C1

Peptidase_C1: Papain family cysteine protease (114 - 332)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

cathepsin L2

  • cathepsin L2, preproprotein

CTSV Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
CTSV O60911 CTSL Homo sapiens P07711
Anti Tag CoIP
33961781
Intra
CTSV O60911 CTSL Homo sapiens P07711
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CTSV Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P7755 Cathepsin L2 Protein, Human (HEK293, His) O60911 (V18-V334) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7755A Cathepsin L2 Protein, Human (HEK293, His, solution) O60911 (V18-V334) ≥ 95%, as determined by reducing SDS-PAGE.

CTSV Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82802 Cathepsin L/V/K/H Antibody (YA2547) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03347 CTSV Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CTSV VGNC VGNC:81385
Mus musculus CTSV MGD MGI:88564
Others CTSV NCBI