Irx3 - Iroquois related homeobox 3 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16373

Summary

Enables DNA-binding transcription activator activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including His-Purkinje system development; energy homeostasis; and regulation of transcription by RNA polymerase II. Acts upstream of or within kidney development; mesoderm development; and regulation of neuron differentiation. Located in axon; cytoplasm; and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; limb; and sensory organ. Orthologous to human IRX3 (iroquois homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Irx3 Products (2)

mRNA Protein Name
NM_001253822.1 NP_001240751.1 iroquois-class homeodomain protein IRX-3 isoform 1
NM_008393.3 NP_032419.2 iroquois-class homeodomain protein IRX-3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
21825130 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
21825130 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21825130 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in His-Purkinje system cell differentiation IMP
IMP: Inferred from mutant phenotype
26786475 MGI
involved in Purkinje myocyte development IMP
IMP: Inferred from mutant phenotype
26786475 MGI
involved in atrioventricular bundle cell differentiation IMP
IMP: Inferred from mutant phenotype
26786475 MGI
involved in energy homeostasis IDA
IDA: Inferred from direct assay
24646999 MGI
acts upstream of or within mesoderm development IGI
IGI: Inferred from genetic interaction
11124112 MGI
involved in metanephros development IEP
IEP: Inferred from expression pattern
17875669 MGI
acts upstream of or within negative regulation of neuron differentiation IDA
IDA: Inferred from direct assay
10830170 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21825130 MGI
acts upstream of neuron differentiation IDA
IDA: Inferred from direct assay
10830170 MGI
involved in positive regulation of gap junction assembly IMP
IMP: Inferred from mutant phenotype
21825130 MGI
acts upstream of or within positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
10830170 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21825130 MGI
involved in proximal/distal pattern formation involved in nephron development IEP
IEP: Inferred from expression pattern
17875669 MGI
acts upstream of regulation of cell communication by electrical coupling involved in cardiac conduction IMP
IMP: Inferred from mutant phenotype
21825130 MGI
involved in specification of loop of Henle identity IEP
IEP: Inferred from expression pattern
17875669 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in axon IDA
IDA: Inferred from direct assay
19666821 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16100003 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16100003 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

iroquois-class homeodomain protein IRX-3

  • homeodomain protein IRXB1

  • iroquois homeobox protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06922 IRX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06925 IRX6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20756 Irx3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27269 Irx3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irx3 NCBI NCBI:79191