Klc2 - kinesin light chain 2 Gene

Also Known as KLC 2; KLC-2; 8030455F02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16594

Summary

Enables Kinesin binding activity. Acts upstream of or within axo-dendritic transport. Located in ciliary rootlet; cytosol; and neuron projection. Part of Kinesin complex. Human ortholog(s) of this gene implicated in SPOAN syndrome. Orthologous to human KLC2 (Kinesin light chain 2). [provided by Alliance of Genome Resources, Apr 2022]

Klc2 Products (4)

mRNA Protein Name
NM_001369360.1 NP_001356289.1 kinesin light chain 2 isoform 1
NM_001369361.1 NP_001356290.1 kinesin light chain 2 isoform 2
NM_001369362.1 NP_001356291.1 kinesin light chain 2 isoform 2
NM_008451.3 NP_032477.2 kinesin light chain 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables kinesin binding IPI
IPI: Inferred from physical interaction
9624122 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11106729 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within axo-dendritic transport IMP
IMP: Inferred from mutant phenotype
16301330 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in ciliary rootlet IDA
IDA: Inferred from direct assay
16018997 MGI
located in ciliary rootlet IPI
IPI: Inferred from physical interaction
16018997 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16018997 MGI
located in cytosol IDA
IDA: Inferred from direct assay
9624122 MGI
part of kinesin complex IDA
IDA: Inferred from direct assay
9624122 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
16301330 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinesin light chain 2

Klc2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Cross
Klc2 Q91YS4 CLSTN1 Homo sapiens O94985-2
FPS
23519214
Cross
Klc2 Q91YS4 CLSTN1 Homo sapiens O94985-2
Anti Tag CoIP
23519214
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-112777 Kinesore 98.0% Unkown
HY-RS07327 KLC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07328 KLC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20291 Klc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26799 Klc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Klc2 NCBI NCBI:64837