Rab8a - RAB8A, member RAS oncogene family Gene

Also Known as Mel

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17274

Summary

Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and Myosin V binding activity. Predicted to be involved in several processes, including cellular response to Insulin stimulus; plasma membrane bounded cell projection organization; and protein transport. Predicted to act upstream of or within autophagy; cell projection organization; and protein transport. Located in several cellular components, including ciliary basal body; ciliary base; and cytoplasmic vesicle. Is expressed in neural retina and photoreceptor layer. Orthologous to human RAB8A (RAB8A, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab8a Products (1)

mRNA Protein Name
NM_023126.2 NP_075615.2 ras-related protein Rab-8A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
11773082 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
25860027 MGI
involved in protein localization to cilium IMP
IMP: Inferred from mutant phenotype
25860027 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in ciliary basal body IDA
IDA: Inferred from direct assay
19625297 MGI
located in ciliary base IDA
IDA: Inferred from direct assay
24947469 MGI
located in ciliary membrane IDA
IDA: Inferred from direct assay
29038301 MGI
located in cilium IDA
IDA: Inferred from direct assay
24469809 MGI
located in cilium IMP
IMP: Inferred from mutant phenotype
20048263 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
20592197 MGI
located in non-motile cilium IDA
IDA: Inferred from direct assay
19625297 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18094055 MGI
located in recycling endosome IDA
IDA: Inferred from direct assay
18094055 MGI
located in trans-Golgi network transport vesicle IDA
IDA: Inferred from direct assay
17765678 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras-related protein Rab-8A

  • cell line NK14 derived transforming oncogene

  • oncogene c-mel

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-136197 StRIP16 Inhibitor 95.38% Unkown
HY-174420 RN277 Inhibitor / Unkown
HY-RS11578 RAB8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22764 Rab8a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29278 Rab8a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rab8a NCBI NCBI:4218