Nfkb2 - nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 Gene

Also Known as lyt; p49; p52; p50B; p49/p100; NF-kappaB2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18034

About Nfkb2

Chromosome 19: 46,292,759-46,300,824 forward strand.GRCm39:CM001012.3

This gene has 8 transcripts (splice variants), 125 orthologues, 4 paralogues and is associated with 125 phenotypes. Broad expression in spleen adult (RPKM 67.), mammary gland adult (RPKM 33.7) and 15 other tissues.

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including NIK/NF-kappaB signaling; follicular dendritic cell differentiation; and germinal center formation. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; musculature; thymus primordium; and trigeminal ganglion. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Nfkb2 Products (3)

mRNA Protein Name
NM_001177369.1 NP_001170840.1 nuclear factor NF-kappa-B p100 subunit isoform a
NM_001177370.1 NP_001170841.1 nuclear factor NF-kappa-B p100 subunit isoform b
NM_019408.3 NP_062281.1 nuclear factor NF-kappa-B p100 subunit isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
22880094 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17254973 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
10586052 MGI
acts upstream of or within follicular dendritic cell differentiation IMP
IMP: Inferred from mutant phenotype
10586052 MGI
acts upstream of or within germinal center formation IMP
IMP: Inferred from mutant phenotype
10586052 MGI
involved in non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
23583643 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
10586052 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in nucleus IDA
IDA: Inferred from direct assay
10402669 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nfkb2 Protein Structure

RHD-n_NFkB2

RHD-n_NFkB2: cd07934 (37 - 220)

IPT_NFkappaB

IPT_NFkappaB: cd01177 (227 - 326)

PHA03095

PHA03095: cl33707 (458 - 704)

ANK

ANK: sd00045 (486 - 523)

ANK

ANK: sd00045 (525 - 556)

ANK

ANK: sd00045 (558 - 585)

ANK

ANK: sd00045 (598 - 629)

ANK

ANK: sd00045 (632 - 664)

ANK

ANK: sd00045 (666 - 697)

Death_NFkB2_p100

Death_NFkB2_p100: cd08798 (773 - 848)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 899 a.a.
Protein Preferred Names Protein Names

nuclear factor NF-kappa-B p100 subunit

  • DNA-binding factor KBF2

  • NF kappaB2

Nfkb2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Nfkb2 Q9WTK5 Relb Mus musculus Q04863
Y2H Array
20211142
Intra
Nfkb2 Q9WTK5 Rela Mus musculus Q04207
Y2H Array
20211142
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-A0024 Tolterodine 98.61% Yes
HY-90010 Tolterodine tartrate 98.64% Yes
HY-90010R Tolterodine tartrate (Standard) / Unkown

Pre-clinical Phase

Bioactive Molecules (8)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P3229 SN52 Inhibitor 99.31% Unkown
HY-149351 NF-κB-IN-10 Inhibitor / Unkown
HY-A0024S Tolterodine-d14 hydrochloride Substrate 99.0% Unkown
HY-RS09257 NFKB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09258 Nfkb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09259 Nfkb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174568 Human NFKB2 mRNA / Unkown
HY-90010S Tolterodine tartrate-d14 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfkb2 NCBI NCBI:4791