2. Gene
  3. Nfkb2 - nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 Gene

Nfkb2 - nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as lyt; p49; p52; p50B; p49/p100; NF-kappaB2

Gene ID: 18034 | Gene type: protein coding

About Nfkb2

Chromosome 19: 46,292,759-46,300,824 forward strand.GRCm39:CM001012.3

This gene has 8 transcripts (splice variants), 125 orthologues, 4 paralogues and is associated with 125 phenotypes. Broad expression in spleen adult (RPKM 67.), mammary gland adult (RPKM 33.7) and 15 other tissues.

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including NIK/NF-kappaB signaling; follicular dendritic cell differentiation; and germinal center formation. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; musculature; thymus primordium; and trigeminal ganglion. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Nfkb2 Products(3)

mRNA Protein Name
NM_001177369.1 NP_001170840.1 nuclear factor NF-kappa-B p100 subunit isoform a
NM_001177370.1 NP_001170841.1 nuclear factor NF-kappa-B p100 subunit isoform b
NM_019408.3 NP_062281.1 nuclear factor NF-kappa-B p100 subunit isoform a

Nfkb2 Protein Structure

RHD-n_NFkB2

RHD-n_NFkB2: cd07934 (37 - 220)

IPT_NFkappaB

IPT_NFkappaB: cd01177 (227 - 326)

PHA03095

PHA03095: cl33707 (458 - 704)

ANK

ANK: sd00045 (486 - 523)

ANK

ANK: sd00045 (525 - 556)

ANK

ANK: sd00045 (558 - 585)

ANK

ANK: sd00045 (598 - 629)

ANK

ANK: sd00045 (632 - 664)

ANK

ANK: sd00045 (666 - 697)

Death_NFkB2_p100

Death_NFkB2_p100: cd08798 (773 - 848)

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  • 899 a.a.
Protein Preferred Names Protein Names

nuclear factor NF-kappa-B p100 subunit

DNA-binding factor KBF2

NF kappaB2

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P3229 SN52 Inhibitor 98.24% Unkown
HY-149351 NF-κB-IN-10 Inhibitor / Unkown
HY-RS09257 NFKB2 Human Pre-designed siRNA Set A / Unkown
HY-RS09258 Nfkb2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09259 Nfkb2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfkb2 NCBI NCBI:4791