NFKB2 - nuclear factor kappa B subunit 2 Gene

Homo sapiens

Also known as p52; p100; H2TF1; LYT10; CVID10; LYT-10; NF-kB2; p49/p100

Gene ID: 4791 | Gene type: protein coding

About NFKB2

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,394,110-102,402,529 (from NCBI)

This gene has 20 transcripts (splice variants), 125 orthologues, 4 paralogues and is associated with 58 phenotypes. Ubiquitous expression in appendix (RPKM 21.5), bone marrow (RPKM 20.6) and 25 other tissues.

Summary

This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

NFKB2 Products(6)

mRNA	Protein	Name
NM_001077494.3	NP_001070962.1	nuclear factor NF-kappa-B p100 subunit isoform a
NM_001322935.1	NP_001309864.1	nuclear factor NF-kappa-B p100 subunit isoform c
NM_001322934.2	NP_001309863.1	nuclear factor NF-kappa-B p100 subunit isoform a
NM_002502.6	NP_002493.3	nuclear factor NF-kappa-B p100 subunit isoform b
NM_001261403.3	NP_001248332.1	nuclear factor NF-kappa-B p100 subunit isoform b
NM_001288724.1	NP_001275653.1	nuclear factor NF-kappa-B p100 subunit isoform b

NFKB2 Protein Structure

RHD_DNA_bind

Ank

Ank_2

Death

0
200
400
600
800
900 a.a.

Protein Preferred Names

Protein Names

nuclear factor NF-kappa-B p100 subunit

DNA-binding factor KBF2	NFKB, p52/p100 subunit
lymphocyte translocation chromosome 10 protein	nuclear factor Kappa-B, subunit 2
nuclear factor NF-kappa-B p52 subunit	nuclear factor of Kappa light chain gene enhancer in B cells 2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	oncogene Lyt-10
transcription factor NFKB2

Related Diseases

Diseases

Alias

Immunodeficiency, Common Variable, 10

CVID10	Deficit In Anterior Pituitary Function And Variable Immunodeficiency
David	Immunodeficiency, Common Variable, With Central Adrenal Insufficiency
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome	David Syndrome
Common Variable Immunodeficiency With Central Adrenal Insufficiency	Immunodeficiency, Variable, Common, Type 10

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

B-Cell Non-Hodgkin Lymphoma

B-Cell Nhl

B-Cell Non-Hodgkins Lymphoma

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Myeloma, Multiple

Multiple Myeloma	Kahler Disease
Myelomatosis	Plasma Cell Myeloma
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Multiple Myeloma, Susceptibility To	Myeloma - Multiple
Kahler'S Disease	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Acth Deficiency, Isolated

Adrenocorticotropic Hormone Deficiency	IAD
Congenital Isolated Acth Deficiency	Isolated Acth Deficiency
Isolated Adrenocorticotropic Hormone Deficiency	Adrenocorticotropic Hormone Deficiency
Adrenocorticotropic Hormone [Acth] Deficiency	Secondary Adrenocortical Insufficiency

Immunodeficiency, Common Variable, 1

CVID1	Antibody Deficiency Due To Icos Defect
Icos Deficiency	Immunodeficiency, Variable, Common, Type 1

Incontinentia Pigmenti

Bloch-Sulzberger Syndrome	IP
Incontinentia Pigmenti, Familial Male-Lethal Type	Incontinentia Pigmenti Syndrome
Bloch-Siemens Syndrome	Ip2
Incontinentia Pigmenti, Type Ii, Formerly	Ip2, Formerly
Incontinentia Pigmenti Type 2	Bloch-Siemens-Sulzberger Syndrome
Familial Incontinentia Pigmenti Male-Lethal Type	Familial Incontinentia Pigmenti Type Ii
Incontinentia Pigmenti, Type Ii	Bloch Sulzberger Syndrome
Incontinentia Pigmenti Achromians	Incontinentia Pigmenti Of Bloch-Sulzberger
Nevus Pigmentosus Systematicus

Osteopetrosis

Albers-Schonberg Disease	Marble Bone Disease
Osteopetroses	Marble Bones
Osteopetrosis And Related Disorders	Congenital Osteopetrosis
Marble Bone	Albers-Schoenberg Disease
Albers-Schonberg Osteopetrosis	Osteosclerosis Fragilis
Ivory Bones

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Transient Hypogammaglobulinemia Of Infancy

Immunoglobulin Maturational Delay

Thi - [Transient Hypogammaglobulinaemia Of Infancy]

Asbestos-Related Lung Carcinoma

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Acquired Hypogammaglobulinemia	Common Variable Immune Deficiency
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3229	SN52	Inhibitor	98.24%	Unkown
HY-149351	NF-κB-IN-10	Inhibitor	/	Unkown
HY-RS09257	NFKB2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS09258	Nfkb2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS09259	Nfkb2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NFKB2	RGD	RGD:1307189
Felis catus	NFKB2	VGNC	VGNC:68482
Mus musculus	NFKB2	MGD	MGI:1099800
Bos taurus	NFKB2	VGNC	VGNC:32044
Canis familiaris	NFKB2	VGNC	VGNC:43781

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