RELB - RELB proto-oncogene, NF-kB subunit Gene

Also Known as IREL; I-REL; IMD53; REL-B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5971

About RELB

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,001,464-45,038,192 (from NCBI)

This gene has 7 transcripts (splice variants), 195 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 14.1), appendix (RPKM 10.1) and 25 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in cytosol and nucleoplasm. Part of chromatin; nucleus; and transcription repressor complex. Colocalizes with centrosome. Implicated in breast Cancer and immunodeficiency 53. Biomarker of breast Cancer and transitional cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

RELB Products (6)

mRNA	Protein	Name
XM_047439190.1	XP_047295146.1	transcription factor RelB isoform X4
XM_047439189.1	XP_047295145.1	transcription factor RelB isoform X3
NM_006509.4	NP_006500.2	transcription factor RelB isoform 1
XM_005259128.3	XP_005259185.1	transcription factor RelB isoform X2
XM_005259127.4	XP_005259184.1	transcription factor RelB isoform X1
NM_001411087.1	NP_001398016.1	transcription factor RelB isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23729669	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14743216	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20873783	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lymphocyte differentiation	IMP IMP: Inferred from mutant phenotype	26385063	GOA
involved in negative regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	22065573	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with centrosome	IDA IDA: Inferred from direct assay	20873783	GOA
located in chromatin	IDA IDA: Inferred from direct assay	23729669	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22065573	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20873783	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	19158276	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RELB Protein Structure

RHD_DNA_bind

0
100
200
300
400
500
579 a.a.

Protein Preferred Names	Protein Names
transcription factor RelB	v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3

RELB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RELB	Q01201	RELA	Homo sapiens	Q04206-2	Anti Tag CoIP	28514442
Intra	RELB	Q01201	NFKB1	Homo sapiens	P19838	Y2H	21988832
Intra	RELB	Q01201	NFKB1	Homo sapiens	P19838	Anti Tag CoIP	33961781
Intra	RELB	Q01201	NFKB2	Homo sapiens	Q00653	Anti Tag CoIP	33961781
Intra	RELB	Q01201	NFKB2	Homo sapiens	Q00653	TAP	14743216
Intra	RELB	Q01201	NFKB2	Homo sapiens	Q00653	Anti Tag CoIP	28514442
Intra	RELB	Q01201	SMARCC1	Homo sapiens	Q92922	Anti Tag CoIP	33961781
Intra	RELB	Q01201	GSK3B	Homo sapiens	P49841	Protein Kinase Assay	21217772
Intra	RELB	Q01201	GSK3B	Homo sapiens	P49841	Anti Bait CoIP	21217772

Cross: Cross-species interaction Intra: Intraspecies interaction

RELB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80306	RelB Antibody (YA098)	WB, ICC/IF, IHC-P, IP	Human
HY-P82107	RelB Antibody (YA1852)	WB, IP	Human, Mouse, Rat
HY-P82107A	RelB Antibody (YA1852)(PBS only)	WB, IP	Human, Mouse, Rat
HY-P86198	RelB Antibody (YA5890)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Pancreatic Ductal Adenocarcinoma	Ductal Adenocarcinoma Of The Pancreas
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Immunodeficiency 53	IMD53
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14645	(-)-DHMEQ	Inhibitor	99.81%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RELB	VGNC	VGNC:69284
Macaca mulatta	RELB	VGNC	VGNC:76894
Rattus norvegicus	RELB	RGD	RGD:2321078
Mus musculus	RELB	MGD	MGI:103289
Canis familiaris	RELB	VGNC	VGNC:45467
Bos taurus	RELB	VGNC	VGNC:33859
Others	RELB	NCBI